Ulipristal Acetate in Symptomatic Uterine Fibroid

Status Terminated

Clinical Trial Summary

This study evaluates the effectiveness and safety of ulipristal acetae (UPA) in women with symptomatic uterine fibroids. Those who fulfilled inclusion/exclusion criteria will be treated UPA at daily dose of 5mg.

Clinical Trial Description

There is increasing evidence approving role of medical therapy in treatment of symptomatic uterine fibroid, in the context of women's desire to preserve fertility or not to undergo operation.

Among these hormonal therapies, ulipristal acetate (UPA) is an orally administered selective progesterone receptor modulator commonly prescribed for treatment of uterine fibroid. This agent acts on causing apoptosis of the muscle cells inside the tumor and reducing the tumor matrix in case of uterine fibroid.

UPA at daily dose of 5 mg has been shown to decrease menstrual blood loss and reduce tumor size after 13 consecutive weeks of treatment. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04132349
Study type	Interventional
Source	M? Ð?c Hospital
Contact
Status	Terminated
Phase	Phase 4
Start date	October 23, 2019
Completion date	April 1, 2020

View Details

See also
Status	Clinical Trial	Phase
Terminated	`NCT04073485` - Microwave Ablation for Uterine Fibroids	N/A
Recruiting	`NCT04519593` - ABSOLUTELY: A Temporary Uterine Blood Supply Occlusion for Laparoscopic Myomectomy in Patients With UTErine LeiomYoma	N/A
Recruiting	`NCT01239641` - High Intensity Focused Ultrasound Ablation Virus Myomectomy to Treat Uterine Fibroids	Phase 4
Recruiting	`NCT04748978` - OPPIuM Technique and Myolysis With Diode Laser Dwls	N/A
Not yet recruiting	`NCT04191603` - TWO DİFFERENT ELECTROSURGERY DEVICES AS MONOPOLAR HOOC AND PLASMAKINETIC BIPOLAR SPATULA EFFECTIVENESS DURING COLPOTOMY	N/A
Completed	`NCT03412890` - LIBERTY EXTENSION: Efficacy and Safety Extension Study of Relugolix in Women With Heavy Menstrual Bleeding Associated With Uterine Fibroids	Phase 3
Completed	`NCT03021720` - Satisfaction of Patients With Trans-Arterial Radial Access: Quality of Life in Uterine Fibroid Embolization Trial	N/A
Recruiting	`NCT04209036` - Can 3D Laparoscopy Improve Surgical Performances in Surgeons in Training?
Completed	`NCT05086770` - Comparison of Pain After Uterine Artery Embolization Using Gelatin Microsphere or Tris-acryl Gelatin Microsphere	N/A
Recruiting	`NCT05416424` - Life Study: Lifestyle Intervention in Fibroid Elimination	N/A
Not yet recruiting	`NCT05695690` - Role of US in Uterine Fibroids in Comparison With MRI Using FIGO Classification
Enrolling by invitation	`NCT06430320` - Ascertaining Longterm Outcomes of Fibroid Treatments
Completed	`NCT04832906` - UA Versus UAE in Treatment of Fibroids	Phase 4
Completed	`NCT03444987` - The Role of Fibroblast Activation in Uterine Fibroid
Active, not recruiting	`NCT06244251` - Comparison Between Laparoendoscopic Single-site Surgery and Multi-port Laparoscopy in Treating Uterine Fibroids	N/A
Not yet recruiting	`NCT06153667` - Bearing nsPVA Embolization for Uterine Artery Embolization (BETTER-UAE)
Not yet recruiting	`NCT03450421` - Safety and Efficacy of Actamax™Adhesion Barrier in Women Undergoing Laparoscopic Abdominopelvic Surgery/Myomectomy	N/A
Not yet recruiting	`NCT05840042` - Epidemiology and Risk Factors of Uterine Fibroids in China
Completed	`NCT04345003` - MR Elastography Parameters Impact on MR-HIFU Efficacy in Uterine Fibroids	N/A
Recruiting	`NCT03118037` - Transcervical Radiofrequency Ablation of Uterine Fibroids Global Registry