Heavy Drinking Clinical Trial
Official title:
A Photoplethysmography Sensor-based Personalized Feedback Intervention for Heavy-drinking Young Adults Targeting Heart Rate Variability, Resting Heart Rate, and Sleep
Verified date | March 2024 |
Source | Yale University |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Heavy alcohol use among young adults is a significant public health problem. Advances in technology may offer an innovative solution. This project will conduct the first controlled test of a feedback intervention for reducing drinking and improving health in young adults by targeting heart rate variability, resting heart rate, and sleep via biosensors and electronic diary methods.
Status | Completed |
Enrollment | 60 |
Est. completion date | June 1, 2023 |
Est. primary completion date | June 1, 2023 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 25 Years |
Eligibility | Inclusion Criteria: - 18-25 years of age - Report = 4 heavy drinking occasions in the past 28 days - Report Alcohol Use Disorders Identification Test- Consumption (AUDIT-C) scores indictive of risk of drinking harm - English Speaking - Have a personal smartphone Exclusion Criteria: - Sleep Disorder History - Night/ Rotating work shift - Travel two or more time zones in the month prior to the study or anticipated travel two or more times during study participation - Clinically severe AUD in past 12 months - Currently enrolled in alcohol or sleep treatment - Current, severe psychiatric illness - Current DSM-V substance use disorder - Positive urine drug screen for a substance other than marijuana |
Country | Name | City | State |
---|---|---|---|
United States | Yale University | New Haven | Connecticut |
Lead Sponsor | Collaborator |
---|---|
Yale University | National Institute on Alcohol Abuse and Alcoholism (NIAAA) |
United States,
Administration, S.A.a.M.H.S. Key substance use and mental health indicators in the United States: Results from the National Survey on Drug Use and Health, Center for Behavioral Health Statistics and Quality. 2019; Available from: https://www.samhsa.gov/data/.
Ahmed, W., Podcast No. 43: Alcohol's effect on sleep, recovery and performance, in Whoop Podcast. 2019.
Anderson, M., Technology Device Ownership: 2015. Pew Research Center 2015.
Beauchaine TP, Thayer JF. Heart rate variability as a transdiagnostic biomarker of psychopathology. Int J Psychophysiol. 2015 Nov;98(2 Pt 2):338-350. doi: 10.1016/j.ijpsycho.2015.08.004. Epub 2015 Aug 11. — View Citation
Black DR, Coster DC. Interest in a stepped approach model (SAM): identification of recruitment strategies for university alcohol programs. Health Educ Q. 1996 Feb;23(1):98-114. doi: 10.1177/109019819602300107. — View Citation
Buccelletti E, Gilardi E, Scaini E, Galiuto L, Persiani R, Biondi A, Basile F, Silveri NG. Heart rate variability and myocardial infarction: systematic literature review and metanalysis. Eur Rev Med Pharmacol Sci. 2009 Jul-Aug;13(4):299-307. — View Citation
Buscemi J, Murphy JG, Martens MP, McDevitt-Murphy ME, Dennhardt AA, Skidmore JR. Help-seeking for alcohol-related problems in college students: correlates and preferred resources. Psychol Addict Behav. 2010 Dec;24(4):571-80. doi: 10.1037/a0021122. — View Citation
Cadigan JM, Lee CM, Larimer ME. Young Adult Mental Health: a Prospective Examination of Service Utilization, Perceived Unmet Service Needs, Attitudes, and Barriers to Service Use. Prev Sci. 2019 Apr;20(3):366-376. doi: 10.1007/s11121-018-0875-8. — View Citation
Caldeira KM, Kasperski SJ, Sharma E, Vincent KB, O'Grady KE, Wish ED, Arria AM. College students rarely seek help despite serious substance use problems. J Subst Abuse Treat. 2009 Dec;37(4):368-78. doi: 10.1016/j.jsat.2009.04.005. Epub 2009 Jun 23. — View Citation
Campos, M. Heart rate variability: A new way to track well-being. 2019 Available from: https://www.health.harvard.edu/blog/heart-rate-variability-new-way-track-well2017112212789.
Carey KB, Scott-Sheldon LA, Carey MP, DeMartini KS. Individual-level interventions to reduce college student drinking: a meta-analytic review. Addict Behav. 2007 Nov;32(11):2469-94. doi: 10.1016/j.addbeh.2007.05.004. Epub 2007 May 17. — View Citation
Carey KB, Scott-Sheldon LA, Elliott JC, Bolles JR, Carey MP. Computer-delivered interventions to reduce college student drinking: a meta-analysis. Addiction. 2009 Nov;104(11):1807-19. doi: 10.1111/j.1360-0443.2009.02691.x. Epub 2009 Sep 10. — View Citation
Castaneda D, Esparza A, Ghamari M, Soltanpur C, Nazeran H. A review on wearable photoplethysmography sensors and their potential future applications in health care. Int J Biosens Bioelectron. 2018;4(4):195-202. doi: 10.15406/ijbsbe.2018.04.00125. Epub 2018 Aug 6. — View Citation
Choi YK, Demiris G, Lin SY, Iribarren SJ, Landis CA, Thompson HJ, McCurry SM, Heitkemper MM, Ward TM. Smartphone Applications to Support Sleep Self-Management: Review and Evaluation. J Clin Sleep Med. 2018 Oct 15;14(10):1783-1790. doi: 10.5664/jcsm.7396. — View Citation
Chung KF, Lee CT, Yeung WF, Chan MS, Chung EW, Lin WL. Sleep hygiene education as a treatment of insomnia: a systematic review and meta-analysis. Fam Pract. 2018 Jul 23;35(4):365-375. doi: 10.1093/fampra/cmx122. — View Citation
Craig CL, Marshall AL, Sjostrom M, Bauman AE, Booth ML, Ainsworth BE, Pratt M, Ekelund U, Yngve A, Sallis JF, Oja P. International physical activity questionnaire: 12-country reliability and validity. Med Sci Sports Exerc. 2003 Aug;35(8):1381-95. doi: 10.1249/01.MSS.0000078924.61453.FB. — View Citation
Cronce JM, Larimer ME. Individual-focused approaches to the prevention of college student drinking. Alcohol Res Health. 2011;34(2):210-21. — View Citation
de Zambotti M, Cellini N, Goldstone A, Colrain IM, Baker FC. Wearable Sleep Technology in Clinical and Research Settings. Med Sci Sports Exerc. 2019 Jul;51(7):1538-1557. doi: 10.1249/MSS.0000000000001947. — View Citation
de Zambotti M, Rosas L, Colrain IM, Baker FC. The Sleep of the Ring: Comparison of the OURA Sleep Tracker Against Polysomnography. Behav Sleep Med. 2019 Mar-Apr;17(2):124-136. doi: 10.1080/15402002.2017.1300587. Epub 2017 Mar 21. — View Citation
Delgado MK, Wanner KJ, McDonald C. Adolescent Cellphone Use While Driving: An Overview of the Literature and Promising Future Directions for Prevention. Media Commun. 2016 Jun 16;4(3):79-89. doi: 10.17645/mac.v4i3.536. — View Citation
Demartini KS, Carey KB. Correlates of AUDIT risk status for male and female college students. J Am Coll Health. 2009 Nov-Dec;58(3):233-9. doi: 10.1080/07448480903295342. — View Citation
DeMartini KS, Fucito LM. Variations in sleep characteristics and sleep-related impairment in at-risk college drinkers: a latent profile analysis. Health Psychol. 2014 Oct;33(10):1164-73. doi: 10.1037/hea0000115. Epub 2014 Aug 18. — View Citation
Falk D, Yi HY, Hiller-Sturmhofel S. An epidemiologic analysis of co-occurring alcohol and drug use and disorders: findings from the National Epidemiologic Survey of Alcohol and Related Conditions (NESARC). Alcohol Res Health. 2008;31(2):100-10. — View Citation
Fonseca P, Weysen T, Goelema MS, Most EIS, Radha M, Lunsingh Scheurleer C, van den Heuvel L, Aarts RM. Validation of Photoplethysmography-Based Sleep Staging Compared With Polysomnography in Healthy Middle-Aged Adults. Sleep. 2017 Jul 1;40(7). doi: 10.1093/sleep/zsx097. — View Citation
Fortuna RJ, Robbins BW, Halterman JS. Ambulatory care among young adults in the United States. Ann Intern Med. 2009 Sep 15;151(6):379-85. doi: 10.7326/0003-4819-151-6-200909150-00002. — View Citation
Friedrich A, Schlarb AA. Let's talk about sleep: a systematic review of psychological interventions to improve sleep in college students. J Sleep Res. 2018 Feb;27(1):4-22. doi: 10.1111/jsr.12568. Epub 2017 Jun 15. — View Citation
Fucito LM, DeMartini KS, Hanrahan TH, Whittemore R, Yaggi HK, Redeker NS. Perceptions of Heavy-Drinking College Students About a Sleep and Alcohol Health Intervention. Behav Sleep Med. 2015;13(5):395-411. doi: 10.1080/15402002.2014.919919. Epub 2014 Jun 12. — View Citation
Fucito LM, DeMartini KS, Hanrahan TH, Yaggi HK, Heffern C, Redeker NS. Using Sleep Interventions to Engage and Treat Heavy-Drinking College Students: A Randomized Pilot Study. Alcohol Clin Exp Res. 2017 Apr;41(4):798-809. doi: 10.1111/acer.13342. Epub 2017 Feb 16. — View Citation
Goldman, D., Investing in the growing sleep-health economy. Prevalence, 2016.
Hasler BP, Kirisci L, Clark DB. Restless Sleep and Variable Sleep Timing During Late Childhood Accelerate the Onset of Alcohol and Other Drug Involvement. J Stud Alcohol Drugs. 2016 Jul;77(4):649-55. doi: 10.15288/jsad.2016.77.649. — View Citation
Hasler BP, Martin CS, Wood DS, Rosario B, Clark DB. A longitudinal study of insomnia and other sleep complaints in adolescents with and without alcohol use disorders. Alcohol Clin Exp Res. 2014 Aug;38(8):2225-33. doi: 10.1111/acer.12474. Epub 2014 Jun 27. — View Citation
Hernando D, Roca S, Sancho J, Alesanco A, Bailon R. Validation of the Apple Watch for Heart Rate Variability Measurements during Relax and Mental Stress in Healthy Subjects. Sensors (Basel). 2018 Aug 10;18(8):2619. doi: 10.3390/s18082619. — View Citation
Hingson RW, Zha W, Weitzman ER. Magnitude of and trends in alcohol-related mortality and morbidity among U.S. college students ages 18-24, 1998-2005. J Stud Alcohol Drugs Suppl. 2009 Jul;(16):12-20. doi: 10.15288/jsads.2009.s16.12. — View Citation
Irwin MR. Why sleep is important for health: a psychoneuroimmunology perspective. Annu Rev Psychol. 2015 Jan 3;66:143-72. doi: 10.1146/annurev-psych-010213-115205. Epub 2014 Jul 21. — View Citation
Kaner EF, Beyer FR, Muirhead C, Campbell F, Pienaar ED, Bertholet N, Daeppen JB, Saunders JB, Burnand B. Effectiveness of brief alcohol interventions in primary care populations. Cochrane Database Syst Rev. 2018 Feb 24;2(2):CD004148. doi: 10.1002/14651858.CD004148.pub4. — View Citation
Kemp AH, Quintana DS. The relationship between mental and physical health: insights from the study of heart rate variability. Int J Psychophysiol. 2013 Sep;89(3):288-96. doi: 10.1016/j.ijpsycho.2013.06.018. Epub 2013 Jun 22. — View Citation
Kinnunen H, Rantanen A, Kentta T, Koskimaki H. Feasible assessment of recovery and cardiovascular health: accuracy of nocturnal HR and HRV assessed via ring PPG in comparison to medical grade ECG. Physiol Meas. 2020 May 7;41(4):04NT01. doi: 10.1088/1361-6579/ab840a. — View Citation
Kloss JD, Nash CO, Horsey SE, Taylor DJ. The delivery of behavioral sleep medicine to college students. J Adolesc Health. 2011 Jun;48(6):553-61. doi: 10.1016/j.jadohealth.2010.09.023. Epub 2010 Dec 18. — View Citation
Leyro TM, Buckman JF, Bates ME. Theoretical implications and clinical support for heart rate variability biofeedback for substance use disorders. Curr Opin Psychol. 2019 Dec;30:92-97. doi: 10.1016/j.copsyc.2019.03.008. Epub 2019 Apr 2. — View Citation
Liu Y, Wheaton AG, Chapman DP, Cunningham TJ, Lu H, Croft JB. Prevalence of Healthy Sleep Duration among Adults--United States, 2014. MMWR Morb Mortal Wkly Rep. 2016 Feb 19;65(6):137-41. doi: 10.15585/mmwr.mm6506a1. — View Citation
Miller MB, DiBello AM, Lust SA, Carey MP, Carey KB. Adequate sleep moderates the prospective association between alcohol use and consequences. Addict Behav. 2016 Dec;63:23-8. doi: 10.1016/j.addbeh.2016.05.005. Epub 2016 May 7. — View Citation
Monk TH, Reynolds CF, Kupfer DJ, Buysse DJ, Coble PA, Hayes AJ, MacHen MA, Petrie SR, Ritenour AM. The Pittsburgh Sleep Diary. J Sleep Res. 1994 Jun;3(2):111-120. — View Citation
NIAAA, Alcohol and Other Drugs. Alcohol Alert, 2008. 76.
NIAAA, Alcohol involvement over the life course, E. U. S. Department of Health and Human Services, Editor. 2000 Bethesda, MD. p. p. 28-53.
O'hara, B. and K. Caswell, Health status, health insurance, and medical services utilization: 2010. Curr Pop Rep, 2012. 2012: p. 70-133.
Ortega FB, Sanchez-Lopez M, Solera-Martinez M, Fernandez-Sanchez A, Sjostrom M, Martinez-Vizcaino V. Self-reported and measured cardiorespiratory fitness similarly predict cardiovascular disease risk in young adults. Scand J Med Sci Sports. 2013 Dec;23(6):749-57. doi: 10.1111/j.1600-0838.2012.01454.x. Epub 2012 Mar 15. — View Citation
Orzech KM, Salafsky DB, Hamilton LA. The state of sleep among college students at a large public university. J Am Coll Health. 2011;59(7):612-9. doi: 10.1080/07448481.2010.520051. — View Citation
Pernice R, Javorka M, Krohova J, Czippelova B, Turianikova Z, Busacca A, Faes L. Reliability of Short-Term Heart Rate Variability Indexes Assessed through Photoplethysmography. Annu Int Conf IEEE Eng Med Biol Soc. 2018 Jul;2018:5610-5513. doi: 10.1109/EMBC.2018.8513634. — View Citation
Pernice R, Javorka M, Krohova J, Czippelova B, Turianikova Z, Busacca A, Faes L; Member, IEEE. Comparison of short-term heart rate variability indexes evaluated through electrocardiographic and continuous blood pressure monitoring. Med Biol Eng Comput. 2019 Jun;57(6):1247-1263. doi: 10.1007/s11517-019-01957-4. Epub 2019 Feb 7. — View Citation
Peters EN, Leeman RF, Fucito LM, Toll BA, Corbin WR, O'Malley SS. Co-occurring marijuana use is associated with medication nonadherence and nonplanning impulsivity in young adult heavy drinkers. Addict Behav. 2012 Apr;37(4):420-6. doi: 10.1016/j.addbeh.2011.11.036. Epub 2011 Dec 3. — View Citation
Pilkonis PA, Choi SW, Reise SP, Stover AM, Riley WT, Cella D; PROMIS Cooperative Group. Item banks for measuring emotional distress from the Patient-Reported Outcomes Measurement Information System (PROMIS(R)): depression, anxiety, and anger. Assessment. 2011 Sep;18(3):263-83. doi: 10.1177/1073191111411667. Epub 2011 Jun 21. — View Citation
Pilkonis PA, Choi SW, Salsman JM, Butt Z, Moore TL, Lawrence SM, Zill N, Cyranowski JM, Kelly MA, Knox SS, Cella D. Assessment of self-reported negative affect in the NIH Toolbox. Psychiatry Res. 2013 Mar 30;206(1):88-97. doi: 10.1016/j.psychres.2012.09.034. Epub 2012 Oct 22. — View Citation
Portnoy DB, Scott-Sheldon LA, Johnson BT, Carey MP. Computer-delivered interventions for health promotion and behavioral risk reduction: a meta-analysis of 75 randomized controlled trials, 1988-2007. Prev Med. 2008 Jul;47(1):3-16. doi: 10.1016/j.ypmed.2008.02.014. Epub 2008 Feb 20. — View Citation
Prinsloo GE, Rauch HG, Derman WE. A brief review and clinical application of heart rate variability biofeedback in sports, exercise, and rehabilitation medicine. Phys Sportsmed. 2014 May;42(2):88-99. doi: 10.3810/psm.2014.05.2061. — View Citation
Ralevski E, Petrakis I, Altemus M. Heart rate variability in alcohol use: A review. Pharmacol Biochem Behav. 2019 Jan;176:83-92. doi: 10.1016/j.pbb.2018.12.003. Epub 2018 Dec 6. — View Citation
Rideout V. Generation Rx.com. What are young people really doing online? Mark Health Serv. 2002 Spring;22(1):26-30. — View Citation
Rideout, V. and S. Fox, Digital health practices, social media use, and mental wellbeing among teens and young adults in the US. 2018.
Roberts DM, Schade MM, Mathew GM, Gartenberg D, Buxton OM. Detecting sleep using heart rate and motion data from multisensor consumer-grade wearables, relative to wrist actigraphy and polysomnography. Sleep. 2020 Jul 13;43(7):zsaa045. doi: 10.1093/sleep/zsaa045. — View Citation
Rounsaville, B.J., K.M. Carroll, and L.S. Onken, A stage model of behavioral therapies research: Getting started and moving on from stage I. Clinical Psychology: Science and Practice, 2001. 8(2): p. 133-142.
Singleton RA Jr, Wolfson AR. Alcohol consumption, sleep, and academic performance among college students. J Stud Alcohol Drugs. 2009 May;70(3):355-63. doi: 10.15288/jsad.2009.70.355. — View Citation
Sobell LC, Agrawal S, Sobell MB, Leo GI, Young LJ, Cunningham JA, Simco ER. Comparison of a quick drinking screen with the timeline followback for individuals with alcohol problems. J Stud Alcohol. 2003 Nov;64(6):858-61. doi: 10.15288/jsa.2003.64.858. — View Citation
Sobell MB, Sobell LC, Leo GI. Does enhanced social support improve outcomes for problem drinkers in guided self-change treatment? J Behav Ther Exp Psychiatry. 2000 Mar;31(1):41-54. doi: 10.1016/s0005-7916(00)00007-0. — View Citation
Stein PK, Pu Y. Heart rate variability, sleep and sleep disorders. Sleep Med Rev. 2012 Feb;16(1):47-66. doi: 10.1016/j.smrv.2011.02.005. Epub 2011 Jun 11. — View Citation
Stepanski EJ, Wyatt JK. Use of sleep hygiene in the treatment of insomnia. Sleep Med Rev. 2003 Jun;7(3):215-25. doi: 10.1053/smrv.2001.0246. — View Citation
Structured Clinical Interview For DSM-V-RV Axis I Disorders Research Version. 2014.
Thayer JF, Ahs F, Fredrikson M, Sollers JJ 3rd, Wager TD. A meta-analysis of heart rate variability and neuroimaging studies: implications for heart rate variability as a marker of stress and health. Neurosci Biobehav Rev. 2012 Feb;36(2):747-56. doi: 10.1016/j.neubiorev.2011.11.009. Epub 2011 Dec 8. — View Citation
Trockel M, Manber R, Chang V, Thurston A, Taylor CB. An e-mail delivered CBT for sleep-health program for college students: effects on sleep quality and depression symptoms. J Clin Sleep Med. 2011 Jun 15;7(3):276-81. doi: 10.5664/JCSM.1072. Erratum In: J Clin Sleep Med. 2011 Aug 15;7(4):420. Tailor, Craig Barr [corrected to Taylor, Craig Barr]. — View Citation
Vaschillo EG, Vaschillo B, Buckman JF, Heiss S, Singh G, Bates ME. Early signs of cardiovascular dysregulation in young adult binge drinkers. Psychophysiology. 2018 May;55(5):e13036. doi: 10.1111/psyp.13036. Epub 2017 Nov 29. — View Citation
Walch O, Huang Y, Forger D, Goldstein C. Sleep stage prediction with raw acceleration and photoplethysmography heart rate data derived from a consumer wearable device. Sleep. 2019 Dec 24;42(12):zsz180. doi: 10.1093/sleep/zsz180. — View Citation
Weinstock J, Petry NM, Pescatello LS, Henderson CE. Sedentary college student drinkers can start exercising and reduce drinking after intervention. Psychol Addict Behav. 2016 Dec;30(8):791-801. doi: 10.1037/adb0000207. Epub 2016 Sep 26. — View Citation
Wong MM, Brower KJ, Fitzgerald HE, Zucker RA. Sleep problems in early childhood and early onset of alcohol and other drug use in adolescence. Alcohol Clin Exp Res. 2004 Apr;28(4):578-87. doi: 10.1097/01.alc.0000121651.75952.39. — View Citation
Wong MM, Brower KJ, Nigg JT, Zucker RA. Childhood sleep problems, response inhibition, and alcohol and drug outcomes in adolescence and young adulthood. Alcohol Clin Exp Res. 2010 Jun;34(6):1033-44. doi: 10.1111/j.1530-0277.2010.01178.x. Epub 2010 Apr 5. — View Citation
Wong MM, Brower KJ, Zucker RA. Childhood sleep problems, early onset of substance use and behavioral problems in adolescence. Sleep Med. 2009 Aug;10(7):787-96. doi: 10.1016/j.sleep.2008.06.015. Epub 2009 Jan 12. Erratum In: Sleep Med. 2010 Jan;11(1):110-1. — View Citation
Wong MM, Robertson GC, Dyson RB. Prospective relationship between poor sleep and substance-related problems in a national sample of adolescents. Alcohol Clin Exp Res. 2015 Feb;39(2):355-62. doi: 10.1111/acer.12618. Epub 2015 Jan 16. — View Citation
Worley SL. The Extraordinary Importance of Sleep: The Detrimental Effects of Inadequate Sleep on Health and Public Safety Drive an Explosion of Sleep Research. P T. 2018 Dec;43(12):758-763. — View Citation
Wu LT, Pilowsky DJ, Schlenger WE, Hasin D. Alcohol use disorders and the use of treatment services among college-age young adults. Psychiatr Serv. 2007 Feb;58(2):192-200. doi: 10.1176/ps.2007.58.2.192. — View Citation
Young HA, Benton D. Heart-rate variability: a biomarker to study the influence of nutrition on physiological and psychological health? Behav Pharmacol. 2018 Apr;29(2 and 3-Spec Issue):140-151. doi: 10.1097/FBP.0000000000000383. — View Citation
Yu L, Buysse DJ, Germain A, Moul DE, Stover A, Dodds NE, Johnston KL, Pilkonis PA. Development of short forms from the PROMIS sleep disturbance and Sleep-Related Impairment item banks. Behav Sleep Med. 2011 Dec 28;10(1):6-24. doi: 10.1080/15402002.2012.636266. — View Citation
* Note: There are 78 references in all — Click here to view all references
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Total drinks consumed | Total drinks consumed will be measured using the Time Line Feedback Assessment. This tools asks subjects to self-report how many drinks they consume during a one month period. The score of this tool is dependent upon the amount of drinks consumed by the subject. Higher scores indicate more alcohol consumption for the given month. | 10 weeks | |
Secondary | Drinks per drinking day | Total drinks per drinking day will be measured using the Time Line Feedback Assessment. This tools asks subjects to self-report how many drinks they consume during a one month period. The score of this measure will be determined by the amount of self-reported alcohol consumption that occurred each day. A heavy drinking day for a man would be =5 drinks per sitting and for a women it would be =4 drinks per sitting. | 10 weeks | |
Secondary | Percent heavy drinking days | Percent of heavy drinking days will be measured using the Time Line Feedback Assessment. This tools asks subjects to self-report how many drinks they consume during a one month period. The score of this measure will be determined by the amount of heavy drinking days that occurred in the given month, for a man this would be =5 drinks per sitting and for a women it would be =4 drinks per sitting. A higher percentage in this category would indicate that there were more heavy drinking days for the subject this month. | 10 weeks | |
Secondary | Self-reported abstinent days | Self-reported abstinent days will be measured using the Time Line Feedback Assessment. This tools asks subjects to self-report how many drinks they consume during a one month period. The score of this measure will be determined by how many days a subject abstains from drinking. A higher score in this area would indicate less drinking days for the subject this month. | 10 weeks | |
Secondary | Alcohol-related consequences | Alcohol related positive consequences will be measured using the PROMIS Alcohol- negative consequences assessment and the PROMIS Alcohol- positive consequences assessment. The negative consequences assessment has 31 questions and the positive consequences assessment has 20 questions. The range for this standardized measure is 0-100 with a mean score of 50. A score above the mean would indicate that the subject experiences more alcohol-related consequences. | 10 weeks | |
Secondary | Sleep quality | Sleep quality will be measured using the PROMIS Sleep- Related Impairment and Sleep Disturbance assessments. The sleep disturbance assessment has 27 questions and sleep related impairment assessment has 16 questions. The range for this standardized measure is 0-100 with a mean score of 50. A score above the mean would indicate that the subject experiences worse sleep quality. | 10 weeks | |
Secondary | Sleep-related impairment | Sleep-related impairment will be measured using the PROMIS Sleep- Related Impairment and Sleep Disturbance assessments. The sleep disturbance assessment has 27 questions and the sleep-related impairment assessment has 16 questions. The range for this standardized measure is 0-100 with a mean score of 50. A score above the mean would indicate that the subject experiences more sleep-related impairments. | 10 weeks | |
Secondary | Sleep Duration | Sleep duration will be measured using data from the PPG device.This tool will measure how long a subject slept each night. Ideally, 7-9 hours of sleep should be obtained per night by young adults and this measure will allow subjects to see if they fall above or below the ideal. | 6 weeks | |
Secondary | Heart Rate Variability (HRV) | Heart rate variability (HRV) will be measured using the PPG Device's HRV daily data. This tool monitors subjects heart rate, HRV can range from person to person, but typically higher HRV would indicate better cardiovascular health. | 6 weeks | |
Secondary | Resting Heart Rate (RHR) | Resting Heart Rate (RHR) will be measured using the PPG Device's RHR daily data. This tool monitors subjects heart rate, RHR can vary anywhere between 40-100 beats per minute. Lower RHR would indicate better cardiovascular health. | 6 weeks |
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