Heartburn Clinical Trial
Official title:
The Effect of Fermented Soy Supplementation on Occasional Heartburn Symptom Relief: A Randomized, Placebo-Controlled, Double-blind Trial
Heartburn is as common gastrointestinal symptom experienced by otherwise healthy adults and
typically manifests as a painful burning sensation in the upper abdomen or in the chest.
Typically, heartburn symptoms are treated with over-the-counter (OTC) medications which may
come with side effects.
There is suggestive evidence of the efficacy of fermented soy (Gastro-AD®) for the heartburn
symptom relief. The aim of the study is to evaluate the effect of a fermented soy on
heartburn symptom relief and time to onset.
Heartburn is as common gastrointestinal symptom experienced by otherwise healthy adults and
typically manifests as a painful burning sensation in the upper abdomen or in the chest.
Usually it is caused by the regurgitation of gastric acid into the esophagus. The prevalence
of heartburn is 10-20% worldwide and is increasing. Typically, heartburn symptoms are treated
with over-the-counter (OTC) medications which may come with side effects.
Gastro-AD® is a commercially available food supplement produced by fermentation of soy by a
specific strain of Lactobacillus. There is suggestive evidence, in vivo as well as in vitro
studies, of the efficacy of fermented soy (Gastro-AD®) for the heartburn symptom relief. The
aim of the study is to evaluate the effect of a fermented soy on heartburn symptom relief and
time to onset. It is hypothesized that the consumption of 1-3 g of fermented soy will relieve
the heartburn symptom severity.
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