Heart Valve Diseases Clinical Trial
Official title:
Academic Leader，Head of Cardiac Surgery,Principal Investigator, Clinical Professor
Until very recently, warfarin is still the best drug of choice for long-term anticoagulation
for patients with mechanical prosthetic heart valve. However, the complication of warfarin
account for 75 percent of the whole complication after the mechanical prosthetic heart valve
replacement.
Interindividual variation in warfarin dose is mediated by multiple factors.Advanced models
using combinations of clinical attributes and genetic factors(CYP2C9, VKORC1, and CYP4F2)
explain 50-75% of variability in warfarin dose requirements.These warfarin dosing models
have the potential to improve patient safety by reducing or eliminating serious adverse
events. The investigators conducted a prospective, randomized, blinded, two arm trial to
test this hypothesis.
n/a
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver), Primary Purpose: Treatment
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