Heart Valve Disease Clinical Trial
Official title:
The Pharmacogenetics of Optimal Warfarin Therapy in Chinese Patients After Heart Valve Replacement.
To value the accuracy of the dosing algorithm published by the International Warfarin
Pharmacogenetics Consortium in Chinese patients after heart valve replacement.
To value the accuracy of warfarin pharmacogenomics algorithm by the algorithm calculated
dose and actual dose in the Chinese patients.
The dosing algorithm published by the International Warfarin Pharmacogenetics Consortium hadn't been verifying by a standard randomized prospective study in Chinese patients after heart valve replacement. And, warfarin will affect people's coagulation, so that probably increase the drainage. We'll analyse the interaction of patients' PT-INR or drainge and oral warfarin dosing. ;
Allocation: Randomized, Endpoint Classification: Pharmacokinetics/Dynamics Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver), Primary Purpose: Treatment
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