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The Evolution of Systemic Microvascular Reactivity in Heart Transplant Patients

Heart Transplantation Clinical Trial

Official title:
The Evolution of Systemic Microvascular Reactivity in Heart Transplant Patients

Clinical Trial Summary

The evolution of systemic microvascular reactivity may aid in the comprehension of cardiovascular physiology in heart transplantation patients, and possibly suggest the non-invasive evaluation of skin microcirculation as an ancillary tool in the clinical evaluation of these patients.

Clinical Trial Description

Introduction: Systemic microvascular reactivity (MR) is an essential component of cardiovascular physiology, being studied through non-invasive techniques in readily accessible body regions, such as the skin surface. Heart transplant (HT) is a treatment considered to selected patients, with advanced heart failure. The main cause of long-term mortality after HT is graft vascular disease (GVD), a condition which starts with endothelial dysfunction. To know the evolution of systemic MR in patients subjected to HT can help to find prognostic factors. Objective: The present study aims to perform the prospective evaluation of systemic MR in adult patients, before and two years after HT, at a quaternary hospital, correlating the findings with clinical variables. Methods: Systemic MR will be evaluated in the skin of the forearm using laser speckle contrast imaging with acetylcholine (ACh) iontophoresis, followed by postocclusive reactive hyperemia (PORH), before and after HT. Measurements will be correlated to patient clinical profile, hemodynamic and echocardiographic data. Expected results: The evolution of systemic MR may aid in the comprehension of cardiovascular physiology in HT patients, and possibly suggest the non-invasive evaluation of skin microcirculation as an ancillary tool in the clinical evaluation of these patients. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05729009
Study type Observational
Source National Institute of Cardiology, Laranjeiras, Brazil
Contact Eduardo Tibirica Tibirica, MD, PhD
Phone +55-21-99914-6075
Email etibi@uol.com.br
Status Recruiting
Phase
Start date October 1, 2022
Completion date December 2024
View Details
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