Thymic Tolerance in Pediatric Heart Transplantation

Status Terminated

Clinical Trial Summary

The investigators hypothesize that injecting donor bone marrow cells into the recipient thymus gland at the time of heart transplantation in children will prove to be feasible and safe. They further hypothesize that recipients receiving donor bone marrow will experience less acute rejection events with reduced long-term requirements for immunosuppressive medications when compared to controls who do not receive marrow but who are managed under an identical immunosuppressive protocol.

Clinical Trial Description

n/a

Study Design

Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double-Blind

Related Conditions & MeSH terms

Heart Transplantation

Clinical Trial Details

NCT number	NCT00151164
Study type	Interventional
Source	National Heart, Lung, and Blood Institute (NHLBI)
Contact
Status	Terminated
Phase	Phase 2
Start date	April 2004
Completion date	October 2007

View Details

See also
Status	Clinical Trial	Phase
Not yet recruiting	`NCT06035991` - First Clinical Evaluation of Heart Transplantation With Grafts Preserved Using an Ex-vivo Extended Perfusion System	N/A
Recruiting	`NCT01927614` - Advanced Cardiac Imaging in Cardiac Allograft Vasculopathy	N/A
Recruiting	`NCT01705015` - Organ Transplantation Rehabilitation: Effect of Bedside Exercise Device and Activity Reinforcement	N/A
Completed	`NCT01655563` - Pharmacogenetic Trial of Tacrolimus After Pediatric Transplantation	Phase 2
Completed	`NCT01028599` - Effect of Physical Training on Oxygen Uptake and Endothelial Function in Heart Transplant Recipients	N/A
Completed	`NCT00531921` - Effects of Donor and Recipient Genetic Expression on Heart, Lung, Liver, or Kidney Transplant Survival	N/A
Terminated	`NCT00420537` - Shift to Everolimus (RAD) Kidney Sparing Study	Phase 4
Enrolling by invitation	`NCT03292861` - The Effect and Safety Profile of Thymoglobulin® in Primary Cardiac Transplant Recipients	Phase 2
Recruiting	`NCT04924491` - Cell Therapy With Treg Cells Obtained From Thymic Tissue (thyTreg) to Prevent Rejection in Heart Transplant Children	Phase 1/Phase 2
Recruiting	`NCT05270902` - Haemoadsorption During Heart Transplantation	N/A
Completed	`NCT05289180` - Brachial Right Ventricle - Endomyocardial Biopsy
Recruiting	`NCT03687723` - Observational Study of the Clinical Use of the OCS™ Heart
Completed	`NCT01091194` - Effect of Exercise After Heart Transplantation	Phase 2
Completed	`NCT01182571` - Exploration of Fatigue, Uncertainty, Depression and Quality of Life in Heart Transplantation Recipients	N/A
Withdrawn	`NCT00780637` - Brachial Artery t-PA Release in Heart Transplant Recipients	N/A
Withdrawn	`NCT00780377` - Intracoronary Bradykinin Mediated t-PA Release in Heart Transplant Recipients	N/A
Terminated	`NCT00678002` - Quality of Life in Pediatric Transplant Patients
Terminated	`NCT00121784` - Heart Spare the Nephron (STN) Study - A Study of CellCept (Mycophenolate Mofetil) and Rapamune (Sirolimus) in Heart Transplant Recipients	Phase 4
Withdrawn	`NCT00572286` - Non-invasive Evaluation of Heart Transplant Rejection- Pilot Study	N/A
Completed	`NCT00123331` - Rapamycin Use in Calcineurin Inhibitor (CNI)-Free Immunosuppression for Stabilization/Improvement of Renal Function After Heart Transplantation	Phase 4