Heart Transplant Clinical Trial
Official title:
Stress Cardiac MRI Using Regadenoson for Evaluation of Nonspecific Allograft Dysfunction
The investigators will use cardiac MRI to measure the myocardial perfusion reserve and amount of myocardial edema and fibrosis in heart-transplant patients with nonspecific allograft dysfunction in contrast to those with normal graft function. The investigators hypothesize that patients with nonspecific allograft dysfunction will demonstrate decreased myocardial perfusion reserve, related to microvascular allograft vasculopathy, compared to those with normal graft function.
Adult heart-transplant patients, excluding those with a GFR less than 30 mL/min/1.73m2,
contraindications to MRI and allergies to either regadenoson or gadolinium contrast, will be
enrolled over 10 months. Patients will be recruited from UC San Diego and San Diego Veterans
Affairs. The investigators will specifically enroll patients with nonspecific allograft
dysfunction and patients with normal graft function.
Brief protocol:
Cardiac MRI is performed. Cine images in standard views are obtained. T2 mapping sequences
are performed on short axis images. For stress imaging, intravenous regadenoson is given as
a 0.4 mg bolus followed by a 5 mL saline flush. After 30 seconds, short-axis images are
acquired for 30 consecutive heartbeats with administration of gadolinium. Rest imaging is
performed 30 minutes after stress imaging. Lastly, late gadolinium enhancement images are
obtained in standard views. Images are analyzed offline by a blinded independent reader.
Patients will be followed for one month after enrollment for MACE.
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