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Biomarkers for Diagnosis, Prognosis, and Targeted Therapy After Heart Transplantation — EMBIO  

Heart Transplant Rejection Clinical Trial

Official title:
Biomarkers for Diagnosis, Prognosis, and Targeted Therapy After Heart Transplantation

Clinical Trial Summary

The objective of this prospective observational single center study is to investigate donor-derived cell-free DNA (ddcfDNA), peripheral blood platelet mRNA, peripheral blood extracellular vesicle mRNA, and peripheral blood leukocyte mRNA expression in recognition of clinically significant endomyocardial biopsy (EMB) proven acute rejection in human heart transplant recipients. In detail, the objective is to develop novel biomarkers and liquid biopsies for diagnosis, prognosis, and targeted molecular therapy for primary graft failure, ischemia-reperfusion injury, acute rejection, and development of late graft failure and cardiac allograft vasculopathy, and for monitoring immunosuppression after heart transplantation.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06064123
Study type Observational [Patient Registry]
Source Helsinki University Central Hospital
Contact Karl B Lemstrom, MD, PhD
Phone +358504272281
Email Karl.Lemstrom@Hus.Fi
Status Recruiting
Phase
Start date January 22, 2019
Completion date December 31, 2025
View Details
See also
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