Heart Rate Clinical Trial
Official title:
The Influence of Magnesium Sulphate Pretreatment on Intubating Conditions During Rapid Sequence Induction
Magnesium had an inhibitory effect on neuromuscular transmission and caused a decrease in
muscle fiber membrane excitability. It reduces the amount of acetylcholine that is released
at the motor nerve terminal by decreasing the calcium conductance of presynaptic
voltage-dependent calcium channels. After pre-treatment with magnesium, an increased speed
of onset and a prolongation of the recovery period of neuromuscular blockade have been
observed with other non-depolarizing neuromuscular blocking agent (NMBA) such as atracurium,
vecuronium and rocuronium. Rocuronium is the currently preferred NMBA used as an alternative
to succinylcholine for rapid tracheal intubation. As an alternative to succinylcholine, high
doses of NMBA have been tested for rapid sequence intubation. This excessively high dose of
rocuronium, however, prolongs the duration of the neuromuscular block and this may not be
warranted in every surgical setting.
The reduction of onset time of rocuronium by magnesium pre-treatment can make intubation
condition more rapid and much better clinically. It will thus be interesting to compare
intubation conditions of a standard intubation dose of rocuronium after magnesium
pre-treatment with high dose of rocuronium or standard dose of rocuronium.
Status | Completed |
Enrollment | 168 |
Est. completion date | March 2011 |
Est. primary completion date | March 2011 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 20 Years to 65 Years |
Eligibility |
Inclusion Criteria: - patients undergoing operation under general anesthesia - American Society of Anesthesiologist physical status I or II - 20-65 year old male or female Exclusion Criteria: - hepatic or renal dysfunction - respiratory or cardiovascular dysfunction - neurologic disorder - neuromuscular disease - pregnancy - body mass index (BMI) >30 kg/m2 or <16.5 kg/m2 - anticipated difficult airway - higher magnesium level than normal range in preoperative evaluation - chronic medication with calcium channel blocker or magnesium - history of known allergy to magnesium sulphate or any other study drugs |
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator)
Country | Name | City | State |
---|---|---|---|
Korea, Republic of | Seoul National University Bundang Hospital | Seongnam-si | Gyeonggi-do |
Lead Sponsor | Collaborator |
---|---|
Seoul National University Bundang Hospital |
Korea, Republic of,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | the intubating conditions | The anesthesiologist also assessed the intubating conditions as per the intubation scoring system of the Good Clinical Research Practice guideline. | 1 minute during intervention | No |
Secondary | mean arterial pressure (MAP) | They were recorded pre-induction (base line), just before intubation, and every minute thereafter for 5 min. | 5 min before intubation, immediate before intubation, post-intubation 1, 2, 3, 4, and 5 min. | No |
Secondary | heart rate (HR) | They were recorded pre-induction (base line), just before intubation, and every minute thereafter for 5 min. | 5 min before intubation, immediate before intubation, post-intubation 1, 2, 3, 4, and 5 min. | No |
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