Clinical Trials Logo

Clinical Trial Summary

Magnesium had an inhibitory effect on neuromuscular transmission and caused a decrease in muscle fiber membrane excitability. It reduces the amount of acetylcholine that is released at the motor nerve terminal by decreasing the calcium conductance of presynaptic voltage-dependent calcium channels. After pre-treatment with magnesium, an increased speed of onset and a prolongation of the recovery period of neuromuscular blockade have been observed with other non-depolarizing neuromuscular blocking agent (NMBA) such as atracurium, vecuronium and rocuronium. Rocuronium is the currently preferred NMBA used as an alternative to succinylcholine for rapid tracheal intubation. As an alternative to succinylcholine, high doses of NMBA have been tested for rapid sequence intubation. This excessively high dose of rocuronium, however, prolongs the duration of the neuromuscular block and this may not be warranted in every surgical setting.

The reduction of onset time of rocuronium by magnesium pre-treatment can make intubation condition more rapid and much better clinically. It will thus be interesting to compare intubation conditions of a standard intubation dose of rocuronium after magnesium pre-treatment with high dose of rocuronium or standard dose of rocuronium.


Clinical Trial Description

n/a


Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator)


Related Conditions & MeSH terms


NCT number NCT01153256
Study type Interventional
Source Seoul National University Bundang Hospital
Contact
Status Completed
Phase N/A
Start date December 2010
Completion date March 2011

See also
  Status Clinical Trial Phase
Completed NCT03832205 - Validation of Respiratory Rate and Heart Rate Measurements by Capaciflectors Placed in Four Locations on the Chest
Completed NCT03723954 - Heart Rate Variations of Golf Fans During the 2018 the Ryder Cup
Withdrawn NCT01026961 - Safety of Phenylephrine Hydrochloride, Acetaminophen, Dimethindene Maleate Compared to Phenylephrine Hydrochloride Alone in Healthy Volunteers Phase 1/Phase 2
Completed NCT00760253 - Compare the Side Effects and Difference Awake Level of Three TCI Propofol Formula in TVOR Patients N/A
Completed NCT00380341 - Effects of Instrument-Applied Spinal Manipulative Therapy on Postureal Control and Autonomic Balance N/A
Completed NCT04179279 - Comparative Analysis of a Non-contact Respiratory and Heart Rate Monitor Vs. a Conventional Clinically Validated Reference Monitor
Completed NCT02469844 - Heart Rate Variability (HRV) Analysis in Patients With Nocturnal Epileptic Seizures
Not yet recruiting NCT00503282 - Urinary Catheter Exchange on Admission of Septic Elderly With Permanent Catheter Before Initiation of Antibiotics N/A
Completed NCT05160207 - Intubation-induced Decrease in Heart Rate as an Indicator for Intraoperative Bradycardia
Withdrawn NCT01701960 - Effect of Local Anesthetic on Hemodynamic Measures During Nasal Surgery N/A
Completed NCT02997800 - The Effect of Intraoperative Labetalol on Time to Discharge Phase 2
Completed NCT03359928 - Acute Physiological and Perceptual Responses to Novel Forms of High-intensity Interval Exercise N/A
Completed NCT05600725 - Novel Cardiac Pacing to Initiate Cardiac Remodeling in Heart Failure N/A
Completed NCT05366049 - The Effect of Methods Used in Oral Antipyretic Administration on the Vital Findings of the Child With Fever N/A
Recruiting NCT05401435 - Reliability of Measuring Blood Pressure With a Smartwatch N/A
Completed NCT01638169 - The Contribution of Heels for Walking Quality Among Children With Muscular Dystrophy N/A
Completed NCT00143988 - Heart Rate and Blood Pressure Response During Exercise and Sexual Activity in Normotensive and Hypertensive Volunteers N/A
Completed NCT03131375 - Dexmedetomidine Reduces Emergence Delirium in Children Undergoing Tonsillectomy With Propofol Anesthesia Phase 2/Phase 3
Completed NCT01612130 - Valerian for Conscious Sedation in Patients Submitted to Impacted Lower Third Molars Surgery N/A
Completed NCT06095635 - Acute Influence of Resveratrol Supplementation and Beet Extract in Recovery After Exercise in Coronary Paths N/A