Heart Rate Clinical Trial
Official title:
The Influence of Magnesium Sulphate Pretreatment on Intubating Conditions During Rapid Sequence Induction
Magnesium had an inhibitory effect on neuromuscular transmission and caused a decrease in
muscle fiber membrane excitability. It reduces the amount of acetylcholine that is released
at the motor nerve terminal by decreasing the calcium conductance of presynaptic
voltage-dependent calcium channels. After pre-treatment with magnesium, an increased speed
of onset and a prolongation of the recovery period of neuromuscular blockade have been
observed with other non-depolarizing neuromuscular blocking agent (NMBA) such as atracurium,
vecuronium and rocuronium. Rocuronium is the currently preferred NMBA used as an alternative
to succinylcholine for rapid tracheal intubation. As an alternative to succinylcholine, high
doses of NMBA have been tested for rapid sequence intubation. This excessively high dose of
rocuronium, however, prolongs the duration of the neuromuscular block and this may not be
warranted in every surgical setting.
The reduction of onset time of rocuronium by magnesium pre-treatment can make intubation
condition more rapid and much better clinically. It will thus be interesting to compare
intubation conditions of a standard intubation dose of rocuronium after magnesium
pre-treatment with high dose of rocuronium or standard dose of rocuronium.
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator)
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