Correlation Between Respiratory Variability of R-R Intervals and Systolic Pressure Variability

Heart Rate Determination Clinical Trial

Official title:

Correlation Between Respiratory Variability of R-R Intervals and in Invasive Systolic Blood Pressure During Changes in Posture and Positive End Expiratory Pressure

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT03267017
• Other study ID #: RRV PPV
• Status: Not yet recruiting
• Phase: N/A
• First received: August 28, 2017
• Last updated: August 29, 2017
• Start date: November 1, 2017
• Est. completion date: May 1, 2019

Study information

• Verified date: August 2017
• Source: Rambam Health Care Campus
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

This prospective study is designed to assess and quantify the correlation between respiratory changes in R-R interval and the respiratory changed in invasive systolic blood pressure in ventilated patients during changes in posture and peak end expiratory pressure (PEEP) and following a fluid bolus

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 40
• Est. completion date: May 1, 2019
• Est. primary completion date: November 1, 2018
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 80 Years

Eligibility

Inclusion Criteria:

• Age 18-80

• Scheduled for surgery under general anesthesia requiring invasive blood pressure monitoring

Exclusion Criteria:

• Heart Rate other than sinus

• Cardiac Pacemaker Status

• Transplanted Heart

Related Conditions & MeSH terms

• Heart Rate Determination

Intervention

Other:
• posture changes
Following induction of general anesthesia and initiation of positive pressure ventilation, patients will be tilted 15 degrees head up for 5 minutes with positive end expiratory pressure of 8 cm H2O, and then 15 degrees head down for 5 minutes with positive end expiratory pressure of 3 cm H2O

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Rambam Health Care Campus

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Statistical Correlation between respiratory variability of R-R interval and systolic blood pressure		From immediately after induction of general anesthesia and mechanical ventilation to 20 minutes later