Clinical Trials Logo
  1. Home
  2. Heart Failure (HF)
  3. NCT05652218

REsynchronization Comparison In LBBB and Normal or Mildly Reduced VENTricular Function With CRT (REINVENT-CRT) — REINVENT  

Left Bundle-Branch Block Clinical Trial

Official title:
REsynchronization Comparison In LBBB and Normal or Mildly Reduced VENTricular Function With CRT (REINVENT-CRT), a Phase I Prospective Randomized Controlled Trial

Clinical Trial Summary

Primary Objective - To determine if implantation of a permanent CRT pacing device (with LB-CRT, or conventional BiV-CRT with a coronary sinus LV lead) can improve electromechanical function, HF symptoms, and natriuretic peptide levels among patients with symptomatic HF, LVEF > 35%, and LBBB.

Clinical Trial Description

This pilot study will be a multicenter randomized controlled trial involving 20 medically stable outpatients with heart failure (HF), preserved or mildly reduced LVEF (>35%), and LBBB. Patients will undergo implantation of a Medtronic Percepta CRT-P with an atrial lead, left bundle branch area pacing (LBBap) lead, and a LV lead. They will then be randomly allocated in a 1:1 fashion to usual care plus LB-CRT (DDD 60-130, LV lead turned off) (active intervention #1) or usual care plus BIV-CRT (DDD 60- 130, LV lead turned on) (active intervention #2). ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05652218
Study type Interventional
Source Inova Health Care Services
Contact Tracy Plummer, BSN
Phone 703.776.3567
Email tracy.plummer@inova.org
Status Recruiting
Phase N/A
Start date February 26, 2023
Completion date December 31, 2024
View Details
See also
  Status Clinical Trial Phase
Completed NCT03614169 - Direct HIS-pacing as an Alternative to BiV-pacing in Symptomatic HFrEF Patients With True LBBB N/A
Recruiting NCT05564689 - Absolute Coronary Flow in Patients With Heart Failure With Reduced Ejection Fraction and Left Bundle Branch Block With Cardiac Resynchronization Therapy
Completed NCT03567096 - LV Only MPP With SyncAV N/A
Enrolling by invitation NCT05903313 - A Study to Evaluate Accuracy and Validity of the Chang Gung ECG Abnormality Detection Software
Completed NCT04221763 - Mechanisms and Innovations in Cardiac Resynchronisation Therapy N/A
Recruiting NCT03303612 - Clinical Monitoring Strategy Versus Electrophysiology-guided Algorithmic Approach With a New LBBB After TAVI N/A
Recruiting NCT05572957 - LBBP as Initial Therapy in Patients With Non-ischemic Heart Failure and LBBB N/A
Recruiting NCT05769036 - Conventional Biventricular Versus Left Bundle Branch Pacing on Outcomes in Heart Failure Patients N/A
Completed NCT04537455 - Non-invasive Mapping Using Ultra-high Frequency Electrocardiography N/A
Active, not recruiting NCT05572736 - Conduction System Pacing Versus Biventricular Resynchronization in Patients With Chronic Heart Failure Phase 3
Recruiting NCT03415945 - Left Ventricular Septal Pacing: Potential Application for Cardiac Resynchronization Therapy N/A
Not yet recruiting NCT06148883 - Management of Patients With New Left Bundle Branch Block After Transcatheter Aortic Valve Implantation N/A
Completed NCT02326493 - Tailor-CRT: Better Application of Cardiac Resynchronization Therapy N/A
Recruiting NCT01415024 - Resynchronization in Paced Heart Failure Patients With Implantable Cardioverter Defibrillator (ICD) Indication Phase 4
Not yet recruiting NCT04328649 - Clinical, Structural and Mechanical Features in Patients With Left Bundle Branch Block.
Not yet recruiting NCT05760924 - Left Bundle Branch Pacing on Outcomes and Ventricular Remodeling in Biventricular CRT Nonresponders N/A
Recruiting NCT05327062 - Cardiac Resynchronization Therapy Delivery Guided Non-Invasive Electrical and Venous Anatomy Assessment N/A
Completed NCT03803995 - Mapping and Pacing of the His Bundle for Heart Failure Patients With Left Bundle Branch Block N/A
Recruiting NCT05434962 - The Left Bundle Cardiac Resynchronization Therapy Trial N/A
Recruiting NCT04128384 - Infranodal Conduction Time During TAVR as Predictor of HAVB N/A