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Clinical Trial Summary

High burden right ventricular (RV) pacing has been shown to increase cardiovascular mortality, incidence of heart failure (HF), worsen left ventricular (LV) function and accelerate the development of atrial fibrillation (AF). High percentage ventricular pacing and wider paced QRS in the setting of normal baseline LV ejection fractions have consistently been shown to be independent risk factors for pacing-induced cardiomyopathy. Left bundle branch pacing (LBBP) has emerged as a potential alternative pacing mechanism that may avoid LV dyssynchrony and pacing-induced LV dysfunction by mimicking native electrical conduction.


Clinical Trial Description

We hypothesize that in patients with high degree AV block with anticipated ventricular pacing >90%, and an EF >35% patients undergoing LBBP will demonstrate a significantly lower number of the primary composite endpoint of cardiovascular death, heart failure events, and change in LVESVi as compared to standard RV pacing. Echos will be performed at baseline, 12, 24, and 36 months. NTproBNPs are performed at baseline and follow-up. There will be a core echo lab, and blinded adjudication of ECGs and events. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05015660
Study type Interventional
Source McGill University Health Centre/Research Institute of the McGill University Health Centre
Contact Jacqueline Joza, MD MSc
Phone 514-934-1934
Email jacqueline.joza@gmail.com
Status Recruiting
Phase N/A
Start date September 1, 2022
Completion date July 1, 2027

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