Heart Arrest Clinical Trial
— EP-PCEHOfficial title:
Passive Leg Raise (PLR) During Cardiopulmonary Resuscitation (CPR): a Randomised Study of Survival in Out-of-hospital Cardiac Arrest (OHCA)
1. Hypothesis The early elevation of the lower extremities during out-of-hospital cardiopulmonary resuscitation increases survival to one month by improving cardiac preload and blood flow to the heart and brain during chest compression.
Status | Recruiting |
Enrollment | 3130 |
Est. completion date | June 2016 |
Est. primary completion date | June 2016 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - Cardiac arrest where the rescue team perform chest compression. Exclusion Criteria: - Persons under 18 years |
Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Single Blind (Outcomes Assessor)
Country | Name | City | State |
---|---|---|---|
Spain | Departament of Nursing. Universitat Rovira i Virgili. | Tarragona |
Lead Sponsor | Collaborator |
---|---|
University Rovira i Virgili | Hospital Universitari Joan XXIII de Tarragona., Public Health Service of Cataluña |
Spain,
Axelsson C, Holmberg S, Karlsson T, Axelsson AB, Herlitz J. Passive leg raising during cardiopulmonary resuscitation in out-of-hospital cardiac arrest--does it improve circulation and outcome? Resuscitation. 2010 Dec;81(12):1615-20. doi: 10.1016/j.resuscitation.2010.08.019. Epub 2010 Sep 16. — View Citation
Dragoumanos V, Iacovidou N, Chalkias A, Lelovas P, Koutsovasilis A, Papalois A, Xanthos T. Passive leg raising during cardiopulmonary resuscitation results in improved neurological outcome in a swine model of prolonged ventricular fibrillation. Am J Emerg Med. 2012 Nov;30(9):1935-42. doi: 10.1016/j.ajem.2012.04.014. Epub 2012 Jul 12. — View Citation
Jiménez-Herrera MF, Azeli Y, Valero-Mora E, Lucas-Guarque I, López-Gomariz A, Castro-Naval E, Axelsson C. Passive leg raise (PLR) during cardiopulmonary (CPR) - a method article on a randomised study of survival in out-of-hospital cardiac arrest (OHCA). BMC Emerg Med. 2014 Jul 4;14:15. doi: 10.1186/1471-227X-14-15. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Increase the Effect of Chest Compressions in cpr | The leg raise is performed during the first minutes of CPR (limit 5 min) and will continue as long as the patients receive chest compression. In Spain the patient is immediate randomized by envelope. If the patient is randomized to PLR, the ambulance crews use a special folding stool that allows the legs to be raised about 20 degrees. | up to 5 min | No |
Secondary | Survival to hospital admission after ROSC | Know the survival after arrived to the hospital after ROSC | 24 hours | No |
Secondary | Survival to one month after ROSC | Know the survival to one month | one month | No |
Secondary | Survival to one year | Know survivals to one year and what is the cerebral function (CPC-score 1, 2). | one year | No |
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