Hydrocortisone in Patients of Out-of-hospital Cardiac Arrest

Status Completed

Clinical Trial Summary

Out-of-hospital cardiac arrest (OHCA) is an important issue for the emergency physicians and co-workers. How to improve the return of spontaneous circulation (ROSC) rate and prognosis of these patients challenges the emergency team. When encounters stress, the hypothalamus of human releases corticotropin releasing hormone, which in turn stimulates the pituitary gland to release ACTH. Then ACTH acts on the adrenal gland to release glucocorticoid to against stress. Foley PJ et al found the dogs with bilateral adrenalectomy had lower ROSC rate during resuscitation than those without surgery[1]. Karl H. Linder et al showed OHCA patients had high serum vasopressin and ACTH level but low serum cortisol level. Besides, the serum cortisol level had a negative correlation with collapse duration (no CPR duration)[2]. Studies also revealed the successfully resuscitated patients had higher serum ACTH and cortisol level than non-resuscitated ones[2,3]. In addition, the serum cortisol level was found to be correlated with short term survival rate and hemodynamic status in resuscitated OHCA patients[3]. Animal study also showed mice receiving higher dosage of hydrocortisone had higher ROSC rate and lower epinephrine requirement than those receiving lower dosage of hydrocortisone or normal saline.

<Reference>

1. Foley PJ, Tacker WA, Wortsman J, Frank S, Cryer PE.;" Plasma catecholamine and serum cortisol responses to experimental cardiac arrest in dogs."Am J Physiol 1987;253:E283-9

2. Lindner KH, Strohmenger HU, Ensinger H, Hetzel WD, Ahnefeld FW, Georgieff M.;" Stress hormone response during and after cardiopulmonary resuscitation."Anesthesiology 1992;77:662-8

3. Schultz CH, Rivers EP, Feldkamp CS, Goad EG, Smithline HA, Martin GB, Fath JJ, Wortsman J, Nowak RM.;"A characterization of hypothalamic-pituitary-adrenal axis function during and after human cardiac arrest."Crit Care Med 1993;21:1339-47

4. Smithline H, Rivers E, Appleton T, Nowak R.;"Corticosteroid supplementation during cardiac arrest in rats."Resuscitation 1993;25:257-64

Clinical Trial Description

n/a

Study Design

Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT00172354
Study type	Interventional
Source	National Taiwan University Hospital
Contact
Status	Completed
Phase	N/A
Start date	October 2004
Completion date	May 2006

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT04078815` - End-of-life Practices in 2019 vs. 2014
Completed	`NCT02816385` - Study of Myocardial Contractility After Cardiac Surgery Under an Anterograde or Retrograde Cardioplegia	N/A
Completed	`NCT02486211` - Amantadine to Speed Awakening After Cardiac Arrest	Phase 2
Recruiting	`NCT02326506` - Evaluation of Drainable Volume Measurements During VA-ELS	N/A
Completed	`NCT00139542` - AED Use in Out-of-Hospital Cardiac Arrest: A New Algorithm Named "One Shock Per Minute"	Phase 3
Completed	`NCT00004560` - Public Access Defibrillation (PAD) Community Trial	Phase 3
Completed	`NCT00000502` - Evaluation of SC-V Versus Conventional CPR	Phase 3
Completed	`NCT03640949` - Vasopressin and Methylprednisolone for In-Hospital Cardiac Arrest	Phase 2/Phase 3
Completed	`NCT03310450` - Tour de Borobudur Troponin Study on Predictors and Synergistic Role of MDA and Hs-CRP Levels
Completed	`NCT02733146` - Histones and Free-plasma DNA After Cardiac Arrest	N/A
Withdrawn	`NCT01082991` - Patient Acuity Rating: a Tool to Prevent In-Hospital Cardiac Arrest	Phase 0
Terminated	`NCT00189423` - ResQ Trial: Impact of an ITD and Active Compression Decompression CPR on Survival From Out-of-Hospital Cardiac Arrest	N/A
Completed	`NCT02858583` - SI + CC Versus 3:1 C:V Ratio During Neonatal CPR	N/A
Completed	`NCT03664557` - Feasibility of REBOA in Refractory Cardiac Arrest	N/A
Completed	`NCT01968148` - Mechanisms of Ultra-acute Hyperglycemia After Successful Resuscitation From Out-of-hospital Cardiac Arrest	N/A
Completed	`NCT00392639` - Clinical and Economical Interest of Endovascular Cooling in the Management of Cardiac Arrest (ICEREA Study)	Phase 4
Recruiting	`NCT06081283` - Antiseizure Medication in Seizure Networks at Early Acute Brain Injury	Phase 4
Recruiting	`NCT05321459` - Predictive Outcome in Comatose Patients
Completed	`NCT02780050` - Influence of Core Muscles Activation Using Physical Fitness on the Performance of Chest Compression	N/A
Withdrawn	`NCT04287842` - Impact if Desflurane Preconditioning on the Content of the Phospho-GSK-3b in the Rat's Neurons in the Model of I/R	Phase 4

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.