Progesterone Clinical Trial
Official title:
Age-Related Hearing Loss: Presbycusis & Its Neural Bases
The purpose of this study was to determine the effects of hormone replacement therapy (HRT) on hearing in post-menopausal women.
Background: Female hormone influences on the development and aging of the auditory system
are not completely understood. The present study retrospectively analyzed and compared
hearing abilities among post-menopausal women taking hormone replacement therapy (HRT),
treated with estrogen and progesterone (E+P); estrogen alone (E), and a third (control -
NHRT) group, matched for age, who did not receive any HRT.
Methods: 126 subjects, (60-86 yr), N=32, E+P; N=31, E; N= 63, NHRT; matched for age and
health status participated. All had relatively healthy medical histories, absence of
significant noise exposure, middle ear problems, major surgeries or current/heavy smoking.
Hearing tests included pure tone audiometry (PTA), tympanometry, distortion-product
otoacoustic emissions (DPOAEs), transient otoacoustic emissions (TEOAEs) and
hearing-in-noise-test (HINT). The latter is a test for speech perception in background
noise: the major complaint of hearing-impaired persons.
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Observational Model: Case Control, Time Perspective: Cross-Sectional
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