Clinical Trials Logo
  1. Home
  2. Healthy Women
  3. NCT06395064
  4. Details
NCT06395064 Clinical Trial

The Effect of Dimenhydrinate on Postoperative Nausea and Vomiting After Abdominal Hysterectomy: Randomized-controlled Trial

Healthy Women Clinical Trial

Official title:
The Effect of Dimenhydrinate on Postoperative Nausea and Vomiting After Abdominal Hysterectomy: Randomized-controlled Trial

Clinical Trial Details — Status: Not yet recruiting

Administrative data
NCT number NCT06395064
Other study ID # 313/2024
Secondary ID
Status Not yet recruiting
Phase N/A
First received
Last updated
Start date May 1, 2024
Est. completion date April 30, 2026

Study information
Verified date April 2024
Source Mahidol University
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

The aim of this clinical trial is to learn if Dimenhydrinate works to prevent postoperative nausea-vomiting in adult women who undergoing abdominal hysterectomy. The primary question is: Does Dimenhydrinate lower the proportion of postoperative nauseavomiting during the day 1 after surgery. Researcher will compare Dimenhydrinate to a placebo (a-look-alike substance that contains no drug) which will give intravenously when the patient come back to the ward, to see if Dimenhydrinate work to prevent nauseavomiting during the postoperative day1. All participants will receive standard treatment during pre-operative, intra-operative and the immediate post-operative periods. Participants will receive Dimenhydrinate or placebo only one dose after discharge from the recovery room. During the day 1 postoperative, participants will report their symptoms and keep a diary of the number of tmes they use additional anti-emetic drugs.

Recruitment information / eligibility
Status Not yet recruiting
Enrollment 160
Est. completion date April 30, 2026
Est. primary completion date December 25, 2025
Accepts healthy volunteers Accepts Healthy Volunteers
Gender Female
Age group 18 Years to 65 Years
Eligibility Inclusion Criteria: - 18-65 years female - undergoing trans abdominal hysterectomy Exclusion Criteria: - undergoing emergency surgery - pregnancy or breastfed women - post delivery less than 6 weeks - history of allergic reaction or precaution to use the protocol drug - BMI less than 18 or more than 30 kg/m2 - Need ICU care after surgery

Study Design

Related Conditions & MeSH terms

Intervention

Drug:
• Dimenhydrinate
Dimenhydrinate 50mg intravenously

Locations
Country Name City State
n/a

Sponsors (1)
Lead Sponsor Collaborator
Preeyaporn Jirakittidul

Outcome
Type Measure Description Time frame Safety issue
Primary occurrence and times of nausea vomiting at ward, 6, 12, 24 hr postoperation
See also
  Status Clinical Trial Phase
Completed NCT02575209 - Gender Differences in Social Cognition in Patients With Schizophrenia of Recent Diagnosis and Healthy Controls Subjects N/A
Active, not recruiting NCT03124160 - Compare Two Copper IUDs: Mona Lisa NT Cu380 Mini and ParaGard Phase 3
Completed NCT01879891 - Exercise Intensity, Metabolic Rate and Insulin Sensitivity N/A
Completed NCT02720783 - Tolerability and Pharmacokinetic Study of Econazole Nitrate Plus Benzydamine HCl Vaginal Pessary Phase 1
Recruiting NCT04143659 - A Study to Evaluate the PK and PD of IM or SQ Injections of Levonorgestrel Butanoate (LB) for Female Contraception Phase 1
Completed NCT01764412 - Study of Serum Hepcidin Rate Variations During Menstrual Cycle N/A
Completed NCT05777265 - The Effects of 16-Week Circuit Training in Healthy Women N/A
Completed NCT05777252 - Effects of 16-Week Circuit Training in Healthy Women N/A
Completed NCT03147703 - Timing of Food Intake Impacts Daily Rhythms of Human Saliva Microbiota N/A
Recruiting NCT05994599 - Comparative Bioavailability Study of Ethinyl Estradiol/Etonogestrel Vaginal Ring Phase 1
Not yet recruiting NCT03961412 - A Family-based Intervention to Improve Pap Test Screening Among Under-screened Chinese American Immigrant Women Early Phase 1
Completed NCT02908503 - Vaginal Film Administration and Placement Study: FLAG N/A
Completed NCT01293591 - Garlic Intake And Biomarkers Of Cancer Risk N/A
Completed NCT02268032 - Assess the Effect of Dehydroepiandrosterone (DHEA) or Other Androgenic Agents Over Markers of Ovarian Reserve Phase 1
Completed NCT02994602 - Study of Serum Testosterone and Nestorone in Females After Secondary Exposure to Nestorone ® (NES) + Testosterone (T) Combined Gel Applied to Shoulders and Upper Arms in Males Phase 1
Completed NCT04189796 - Jarlsberg Cheese Compared to Camembert Cheese N/A
Recruiting NCT03432416 - Study of Efficacy, Cycle Control, and Safety of a NES-E2 Contraceptive Vaginal Ring Phase 2
Unknown status NCT01809405 - Validation of Sexual Function Scale in Female Cancer N/A
Completed NCT03412617 - Diets, Metabolic Profile and Gut Microbiota Among Indonesian Women in Minangkabau and Sundanese-ethnic Community N/A
Completed NCT02112903 - Study Comparing the Gastro-intestinal Tolerability and Absorption Profile of Vortioxetine After Administration of Modified-release Formulations and Immediate-release Formulation in Healthy Women Phase 1