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Clinical Trial Summary

The purpose of this study is to assess the effect of PC14586 pharmacokinetics when co administered with itraconazole in healthy participants.


Clinical Trial Description

PC14586 is a first-in-class, oral, small molecule p53 reactivator that is selective for the TP53 Y220C mutation. This is a Phase 1, open-label, fixed-sequence study to investigate the effect of coadministration of itraconazole on the pharmacokinetics (PK) of PC14586 (rezatapopt) in healthy male and female participants. Potential participants will be screened to assess their eligibility to enter the study within 56 days prior to the first dose administration. Participants will be admitted into the study site on Day -1 and be confined to the study site until discharge on Day 33. Participants will return to the study site for PK sample collection on Day 37 and a follow-up visit and PK sample collection on Day 42. Approximately 16 participants will be enrolled in this study. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT06362642
Study type Interventional
Source PMV Pharmaceuticals, Inc
Contact PMV Pharma Clinical Study Information Center
Phone 609-235-4038
Email clinicaltrials@pmvpharma.com
Status Recruiting
Phase Phase 1
Start date March 28, 2024
Completion date December 2024

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