a Safety and Tolerability Study of EP-9001A in Healthy Volunteers

Healthy Volunteers Clinical Trial

Official title:

A Randomized, Double-blind, Placebo-controlled Dose Escalation Phase Ia Clinical Trial to Evaluate the Safety, Tolerability, Pharmacokinetics, and Immunogenicity of EP-9001A Injection in Healthy Subjects

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT05278611
• Other study ID #: EP-9001A-Ia
• Status: Recruiting
• Phase: Phase 1
• Start date: March 23, 2022
• Est. completion date: December 2022

Study information

• Verified date: March 2022
• Source: Chengdu Easton Biopharmaceuticals Co,Ltd
• Contact: ping feng, MD
• Phone: +86 153 8821 6625
• Email: 617130961[@]qq.com
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Nerve Growth Factor（NGF）plays an important role in the pathogenesis of neuropathic pain including cancer pain. EP-9001A is a humanized monoclonal antibody targeting NGF, thus thought to alleviate neuropathic pain though the blockade of NGF signal pathway.

The primary objective of the study is to assess the safety and tolerability of a single dose of subcutaneous (SC) administered EP-9001A in healthy Chinese subjects.

Description:

Nerve Growth Factor（NGF）plays an important role in the pathogenesis of neuropathic pain including cancer pain. EP-9001A is a humanized monoclonal antibody targeting NGF, thus thought to alleviate neuropathic pain though the blockade of NGF signal pathway.

The primary objective of the study is to assess the safety and tolerability of a single dose of subcutaneous (SC) administered EP-9001A in healthy Chinese subjects.

The initial dose of the study was set as 1 mg, and the doses were escalated sequentially in the order of 1 mg, 2.5 mg, 5 mg, 10 mg, 20 mg, and 25 mg

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 44
• Est. completion date: December 2022
• Est. primary completion date: September 2022
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 45 Years

Eligibility

Inclusion Criteria:

1. Healthy male or female Chinese volunteers =18 and =45 years of age at the screening visit;

2. Body weight = 45.0 kg for female subjects and = 50.0 kg for male subjects with a body mass index (BMI) between 19.0 and 26.0 kg/m2( including border value);

3. Subjects during the trial (female subjects from 14 days before dosing, male subjects from dosing) to 3 months after the end of the trial without fertility or sperm/egg donation plan and voluntarily take effective physical contraception measures;

4. According to the results of physical examination, vital signs, ECG and clinical laboratory tests during the screening period, all the test results are normal or abnormal without clinical significance as judged by the investigator;

5. Signed a written informed consent.

Exclusion Criteria:

1. history of allergic diseases (including but not limited to asthma, urticaria, allergic rhinitis), or a history of drug allergy, or a history of allergy to the test drug ingredients;

2. history of clinical serious diseases and not cured, such as motor (muscle and bone) system, digestive system, respiratory system, genitourinary system, blood (hematopoietic) system, circulatory system, nervous system, mental system, endocrine system, cardiovascular system and metabolic abnormalities;

3. received surgery in the past 3 months or have surgery plan during the trial ;

4. Have used any prescription, over-the-counter or health care products in the past 2 weeks;

5. took more than 10 cigarettes a day or the same amount of tobacco or can not stop tobacco during trial;

6. alcohol breath test positive;

7. History of alcohol abuse within the past 6 months;

8. History of drug abuse, positive results of urine multiple drug tests;

9. Drink excessive tea, grapefruit juice, coffee or caffeinated beverages (an average of more than 8 cups per day, 200 mL per cup) every day in the past 1 month;

10. Participated in other drug clinical trials in the past 3 months, or plan to participate in other clinical trials during this study;

11. Blood loss/blood donation of more than 400 mL in the past 3 months (except for female physiological blood loss), or receiving blood transfusion or use of blood products, or planning to donate blood during the trial or within 1 month after the end of the trial;

12. Vaccinated within the past 1 month

13. positive in Hepatitis B surface antigen, hepatitis C antibody, human immunodeficiency virus antibody, syphilis specific antibody screening;

14. Subjects who are lactating, pregnant or plan to become pregnant or conceive recently;

15. Patients with a history of bone or joint diseases, including but not limited to osteoarthritis, pathological fractures, osteonecrosis, rheumatoid arthritis, neuropathic arthritis, lupus erythematosus or inflammatory joint diseases;

16. Patients with a history of joint-related events, such as total joint replacement (TJR) surgery, meniscus or knee ligament injury (with or without surgical repair) or joint infection, or bone dislocation, hip dislocation, knee dislocation within 1 year before screening;

17. Kellgren-Lawrence grade = 2 in any major joint (shoulder, hip, knee);

18. History of clinically significant peripheral neuropathy, paresthesia, dysesthesia;

19. History of autonomic neuropathy or diabetic neuropathy;

20. The investigator assesses the poor compliance, or the investigator believes that the subject has any other conditions that are not suitable for participating in this clinical study

Related Conditions & MeSH terms

• Healthy Volunteers

Intervention

Drug:
• EP-9001A
The initial dose of the study was set as 1 mg, and the doses were escalated sequentially in the order of 1 mg, 2.5 mg, 5 mg, 10 mg, 20 mg, and 25 mg
• placebo
placebo

Locations

Country	Name	City	State
China	West China Hospital,Sichuan University	Chengdu	Sichuan

Sponsors (1)

Lead Sponsor	Collaborator
Chengdu Easton Biopharmaceuticals Co,Ltd

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Number and severity of Adverse Events,MTD	All adverse events occurring throughout the study were assessed and graded. the maximum tolerated dose (MTD)	Baseline to week 8
Secondary	pharmacokinetics of EP-9001A	EP-9001A serum concentrations over time	Baseline to week 8
Secondary	immunogenicity assessed by ADA	Presence of anti-drug antibodies over time	Baseline to week 8