Healthy Volunteers Clinical Trial
Official title:
A Fixed Sequence, Open-label Study to Assess the Effect of Multiple Doses of AZD4831 on the Pharmacokinetics of Oral Midazolam (a CYP450 3A Probe) in Healthy Subjects
The study is an open-label, fixed-sequence, cross-over study conducted at a single Clinical Unit to assess the pharmacokinetics (PK) of midazolam in healthy male and female (non-childbearing potential) subjects when administered alone and in combination with AZD4831 after multiple doses (once daily) of AZD4831 for 10 consecutive days.
The study will consist of 2 treatment periods and will comprise: - A Screening period of maximum 28 days; - Treatment Period 1 and Treatment Period 2: Treatment Period 1: Midazolam only (Day 1). Treatment Period 2: AZD4831 only (Days 2 to 10, once daily dosing) and AZD4831 plus midazolam (Day 11). - A final Follow-up Visit after the last administration of investigational medicinal product (IMP) (Day 20 [± 1 day]). Each subject will be involved in the study for approximately 7 weeks. ;
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