| Eligibility |
Inclusion Criteria:
- Has the ability to understand the requirements of the study and a willingness to
comply with all study procedures and has provided written informed consent before any
study-related procedures are conducted, and is willing to comply with all study
procedures for the duration of the study;
- Has a body mass index (BMI) =18 and =32 kilograms per square meter (kg/m^2), at
screening;
- Has a body weight =50 kg at screening;
- Is medically healthy, with no clinically significant conditions or abnormalities, as
determined by the investigator or designee, through evaluation of medical history and
vital sign measurements, 12-lead ECG results, physical examination findings, and
clinical laboratory test results (congenital nonhemolytic hyperbilirubinemia [eg,
suspicion of Gilbert's syndrome based on total and direct bilirubin] is not
acceptable) at screening and check-in;
- If female:
- Is of childbearing potential and agrees to either abstain from sexual intercourse
with a male partner or agrees to use a highly effective form of contraception,
beginning at screening and continuing throughout the study and for 28 days after
dosing or is postmenopausal (defined as 12 months or more continuously with no
menses), or
- Has a documented medical history of tubal ligation or hysterectomy;
- The following are considered highly effective forms of contraception: hormonal
oral contraceptives, injectables, and patches; intrauterine devices; double
barrier methods (synthetic condom, diaphragm, or cervical cap used with
spermicidal foam, cream, or gel); and male partner sterilization;
- If male (even if vasectomized):
- Agrees to either abstain from sexual intercourse with a female partner, or
- Agrees to use a highly effective form of contraception (as defined above),
starting at screening and continuing until 90 days after the final dose of
mitapivat, and
- Agrees to not donate sperm throughout the entirety of the study until 90 days
after the final dose of mitapivat;
- Agrees to abstain from any alcohol consumption, starting 72 hours prior to check-in
and continuing until the follow-up telephone call;
- Agrees to refrain from marijuana- or cannabinol-containing products for 7 days prior
to screening until after the follow-up telephone call.
Exclusion Criteria:
- At screening, presents with a condition or has a medical history that, in the opinion
of the investigator, may potentially interfere with study drug absorption,
distribution, metabolism, and/or excretion (eg, malabsorption [including due to cystic
fibrosis, lactose intolerance, celiac disease]);
- At screening, presents with a surgical history that, in the opinion of the
investigator, may potentially interfere with study drug absorption, distribution,
metabolism, and/or excretion (eg, cholecystectomy). Participants who have undergone
abdominal surgery or any other major surgical procedure within 6 months prior to
screening, must not be enrolled;
- Has a history or a presence of a primary malignancy, with the exception of a
malignancy that has been curatively treated and for which the participant has
displayed no evidence of disease within 12 months prior to screening;
- Has a known history or presence of liver disease;
- Is pregnant or breastfeeding;
- Has a positive test result for hepatitis B surface antigen (HBsAg), hepatitis C virus
antibody (HCVAb), or human immunodeficiency virus (HIV) types 1 or 2 antibodies at
screening;
- Has liver test results including alanine aminotransferase (ALT), aspartate
aminotransferase (AST), alkaline phosphatase, and total bilirubin that are above the
upper limit of normal at screening or check-in (out-of-range test results may be
repeated once at screening and check-in, if needed);
- Has estimated glomerular filtration rate (eGFR) <60 milliliters per minute
(mL/min)/1.73 m^2 using the Chronic Kidney Disease Epidemiology Collaboration
(CKD-EPI) 2009 equation;
- Has platelet, hemoglobin, or hematocrit test results that are below the lower limit of
normal at screening or check-in (out-of-range test results may be repeated once at
screening and check-in, if needed);
- Has confirmed (ie, 2 consecutive measurements) systolic blood pressure (BP) >150 or
<90 millimeters of mercury (mmHg), diastolic blood pressure (BP) >90 or <50 mmHg, and
pulse rate >100 or <45 beats per minute (bpm) at screening and check-in;
- Has clinically significant cardiac history or presence of ECG findings as determined
by the investigator at screening and check-in, including any of the following:
- Abnormal sinus rhythm (heart rate [HR] lower than 45 bpm and higher than 100
bpm);
- Risk factors for torsades de pointes (eg, heart failure, cardiomyopathy, or
family history of long QT syndrome);
- Sick sinus syndrome, second- or third-degree atrioventricular block myocardial
infarction, pulmonary congestion, cardiac arrhythmia, prolonged QT interval, or
conduction abnormalities;
- QT interval corrected for HR using Fridericia's formula (QTcF) >450 milliseconds
(msec) (male participants) or >450 msec (female participants). In the event a
QTcF value is outside of the reference range, it will be confirmed by 2 further
repeat measurements, which will then be used to calculate a mean from the
original value and the 2 repeat measurements;
- QRS interval >110 msec, confirmed by manual over read;
- PR interval <120 and >220 msec;
- Repeated or frequent syncope or vasovagal episodes;
- Hypertension, angina, bradycardia (if assessed as clinically significant by the
investigator), or severe peripheral arterial circulatory disorders;
- Has clinically significant laboratory assessment findings, including hypokalemia,
hypercalcemia, or hypomagnesemia;
- Has an active infection requiring systemic antimicrobial therapy at any time during
the screening period;
- Has a positive urine drug screen (including cotinine) at screening or check-in;
- Has a positive alcohol breath test result or positive urine drug screen at screening
or check-in;
- Uses or intends to use any medications/products known to alter drug absorption,
metabolism, or elimination processes, including any over-the-counter medications or
herbal or nutritional supplements with the exception of vitamins, within 14 days (or 5
half-lives, whichever is longer) prior to check-in and until the follow-up telephone
call, unless deemed acceptable by the investigator (or designee). Note: After first
dosing, acetaminophen (up to 2 grams per 24 hours) may be administered at the
discretion of the investigator or designee;
- Has used any prescription (excluding hormone replacement therapy and hormonal birth
control) medications, including systemic antimicrobial therapies, within 30 days (or 5
half-lives, whichever is longer) before the first dose of study drug or during the
study (ie, through the follow-up telephone call);
- Is currently enrolled in or has participated in another clinical study to receive any
investigational or marketed product or placebo within 2 months (or 5 half-lives,
whichever is longer) prior to check-in;
- Has donated blood or blood products or experienced blood loss of >450 mL within 30
days prior to check-in;
- Has received blood products within 2 months prior to check-in;
- Has consumed caffeine- or xanthine-containing products within 24 hours prior to first
dose of study drug until after the follow-up telephone call;
- Has consumed foods or beverages containing grapefruit or Seville oranges for 7 days
prior to the first dosing and is not willing to refrain from consumption of these
foods or beverages throughout the study;
- Has ingested poppy seeds within 7 days prior to check-in until after the follow-up
telephone call;
- Has consumed vegetables from the mustard green family (eg, kale, broccoli, watercress,
collard greens, kohlrabi, Brussel sprouts, and mustard greens), or charbroiled meats
within 7 days prior to first dose of study drug or throughout the study;
- Has used nicotine-containing products (eg, snuff, nicotine patch, nicotine chewing
gum, mock cigarettes, vaporizers, or inhalers) within 6 months prior to screening,
based on participant self-reporting, and does not agree to abstain from use until the
follow-up telephone call;
- Has a history of active alcoholism or drug/chemical abuse within 2 years prior to
check-in;
- Average alcohol consumption of >21 units per week for males and >14 units for females
(1 unit is equal to approximately 1/2 pint [200 mL] of beer, or 1 small glass [100 mL]
of wine, or 1 measure [25 mL] of 40% spirits);
- Has a history of relevant drug and/or food allergies (ie, allergy to study drug or
excipients [microcrystalline cellulose, croscarmellose sodium, sodium stearyl
fumarate, magnesium stearate, and mannitol]);
- Has veins that are unsuitable for multiple venipunctures/cannulation, as assessed by
the investigator or designee at screening;
- Is involved in strenuous activity or contact sports within 24 hours prior to check-in
or throughout the study;
- Has any medical, hematological, psychological, or behavioral condition(s) or prior or
current therapy that, in the opinion of the investigator, may confer an unacceptable
risk to participating in the study and/or could confound the interpretation of the
study data;
- Has a positive test for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Note: Testing will be performed according to site procedures.
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