Healthy Volunteers Clinical Trial
Official title:
Generation of Biological Samples Positive to Testosterone for Anti-doping Control
Background:
Testosterone is a steroid widely known to improve physical performance due to its
protein-anabolic effect. Like other androgenic anabolic steroids (EAA), testosterone is
included on the World Anti-Doping Agency (WADA) list of prohibited substances.
EAA are the most detected banned substances in anti-doping controls. Therefore, different
analytical strategies are required to improve its detection.
Hypothesis:
The intramuscular administration of 250 mg of testosterone (cypionate) in healthy subjects
allows generating detectable concentrations of the drug in urine. Positive urine samples will
enable to identify analytical strategies for doping control.
Objectives:
Primary objective: To measure the concentrations of testosterone in urine for anti-doping
control samples.
Secondary objective: To identify metabolites and precursors of testosterone in urine. To
assess safety and tolerability of the drug used.
Methods:
Phase I, open, non-randomized clinical trial, with a treatment condition (testosterone)
administered via intramuscular injection to 4 subjects.
n/a
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