Clinical Trials Logo
  1. Home
  2. Healthy Volunteers
  3. NCT03777488

Pharmacokinetics of Tranexamic Acid After Oral, Intramuscular or Intravenous Administration: a Prospective, Randomised, Cross-over Trial in Healthy Volunteers. — PharmacoTXA  

Healthy Volunteer Study Clinical Trial

Official title:
Pharmacokinetics of Tranexamic Acid After Oral, Intramuscular or Intravenous Administration: a Prospective, Randomised, Cross-over Trial in Healthy Volunteers.

Clinical Trial Summary

This is a Phase 1 study which aims to determine the pharmacokinetics and local and systemic tolerance of tranexamic acid in healthy volunteers using a population approach after oral, intramuscular or intravenous administration. It will also determine the feasibility of measuring tranexamic acid in spots of dry capillary blood.

Clinical Trial Description

Fifteen healthy volunteers will receive in random order 1 gram of intravenous and intramuscular injections and 2 grams of oral tranexamic acid solution. Blood samples will be taken at: - T0+ 5min (only for IV route) - T0+30min - T0+1h - T0+2h - T0+3h - T0+4h - T0+5h - T0+6h - T0+8h (only for IM and PO routes) - T0+24h ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03777488
Study type Interventional
Source London School of Hygiene and Tropical Medicine
Contact
Status Completed
Phase Phase 1
Start date October 30, 2019
Completion date October 14, 2020
View Details
See also
  Status Clinical Trial Phase
Completed NCT03270878 - Glasdegib Absolute Bioavailability Study Phase 1
Completed NCT03086278 - A Study of AST-008 in Healthy Subjects Phase 1
Completed NCT04711187 - Study of AT-527 in Healthy Subjects (R07496998) Phase 1
Completed NCT06141889 - Pharmacokinetics Study of Azelaprag (BGE-105) in Older Adult Healthy Volunteers Phase 1
Completed NCT05154123 - Drug-drug Interaction Study of Rosuvastatin and AT-527 (R07496998) Phase 1
Completed NCT05179421 - Dose Ranging Study of Intravenous Oxytocin for Analgesia to Heat Pain Phase 2
Completed NCT03945344 - Effect of Charcoal on Gastrointestinal Absorption of Tiotropium Phase 1
Recruiting NCT05881993 - Study of CBP-4888 in Healthy, Non-Pregnant Female Subjects Early Phase 1
Completed NCT04242953 - Study to Determine Safety, Tolerability and Pharmacokinetics, of SCO-120 in Healthy Male and Post-menopausal Female Subjects Phase 1
Completed NCT02393950 - Safety, Tolerability,Pharmacokinetics and Pharmacodynamics of ODM-106 in Healthy Volunteers Phase 1
Completed NCT00866385 - AZD8566 Food Effect/Microtracer Study Phase 1
Completed NCT04784000 - Effect of Carbamazepine on the Pharmacokinetics (PK) of AT-527 Phase 1
Completed NCT01609218 - A Study of LY2140023 in Healthy Participants Phase 1
Completed NCT02503085 - Ibuprofen Suspension Bioequivalence Study Phase 1
Completed NCT05004415 - Mass Balance Study of AT-527 in Healthy Adult Male Subjects (R07496998) Phase 1
Completed NCT02256423 - A Study Comparing Three Formulations of Ibuprofen in Healthy Subjects Phase 1
Completed NCT01425450 - Safety Study of Four Doses of the Study Drug, HF1020 in Healthy Volunteers Phase 1
Completed NCT05731843 - Drug-drug Interaction Study of Ruzasvir and Bemnifosbuvir Phase 1
Completed NCT03031535 - Study of Intranasal Octreotide (DP1038) in Healthy Adult Volunteers Phase 1
Completed NCT02452450 - Ibuprofen and Paracetamol Pharmacokinetic Study Phase 1