Healthy Volunteers Clinical Trial
Official title:
Study of Probiotic Potential of Nasopharyngeal Lactobacillus Strains in the Upper Respiratory Tract After Nasal Spray Application
Probiotics are defined as "live micro-organisms that, when administered in adequate amounts,
confer a health benefit to the host" (Hill et al, 2014). These microbes are generally applied
in the gastrointestinal tract via fermented food products or capsules. In previous research,
the investigators isolated bacterial strains with potential probiotic properties for the
upper respiratory tract based on in vitro laboratory tests, in vivo mice experiments and
genome sequencing.
In this study, the investigators want to deliver the Proof-of-Concept that the most promising
isolated strain, Lactobacillus casei AMBR2 (LAMBR2) and the well-documented probiotic strain
Lactobacillus rhamnosus GG (LGG) also have interesting properties in humans, i.e. that these
strains are able to -temporarily- persist in the upper respiratory tract of healthy
volunteers and CRS patients after daily nasal application via a nasal spray for 2 weeks. In
addition, the investigators aim to explore whether the application of these strains has an
impact on the nasopharyngeal microbiome via 16S rRNA amplicon sequencing and dedicated qPCR
analysis.
Therefore, bacterial DNA from nasal swabs will be isolated via commercially available DNA
extraction kits, followed by Illumina MiSeq sequencing in order to identify the bacterial
species present in these samples. Furthermore, the concentration of the Lactobacillus and
specific pathogens will be monitored via qPCR.
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