Healthy Volunteers Clinical Trial
Official title:
Phase 1 Test-retest Evaluation of [18F]MNI-958 PET as an Imaging Marker for Tau Protein in the Brain of Patients With Alzheimer's Disease and Probable PSP as Compared to Healthy Volunteers
The overall goal of this protocol is to evaluate [18F]MNI-958 also known as APN-0000455 or PM-PBB3, a tau targeted radiopharmaceutical.
The overall goal of this protocol is to evaluate [18F]MNI-958 also known as APN-0000455 or
PM-PBB3, a tau targeted radiopharmaceutical. The specific objectives are:
- To measure the dynamic uptake and washout of [18F]MNI- 958 in brain using positron
emission tomography (PET) in patients with Alzheimer's disease, Progressive Supranuclear
Palsy and healthy volunteers.
- To measure blood metabolites of [18F]MNI-958 and perform kinetic modeling to assess its
ability to measure tau protein in brain using the tracer plasma concentration or a
reference region as indirect input.
- To obtain test/retest reliability of the tracer binding parameters in patients with
Alzheimer's disease, Progressive Supranuclear Palsy and healthy volunteers.
- To acquire safety data following injection of [18F]MNI-958.
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