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NCT03469037 Clinical Trial

Effects on Experimental Dyspnea of High Flow Nasal Cannula

Healthy Volunteers Clinical Trial

— EDEN  

Official title:
Effects on an Experimental Dyspnea by Thoraco-abdominal Elastic Strapping of the High Flow Nasal Cannula

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT03469037
Other study ID # 2018-A00178- 47
Secondary ID
Status Completed
Phase N/A
First received
Last updated
Start date May 22, 2018
Est. completion date November 2, 2018

Study information
Verified date February 2019
Source Association pour le Développement et l'Organisation de la Recherche en Pneumologie et sur le Sommeil
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

To develop an experimental model of dyspnea by external thoraco-abdominal elastic strapping at rest in order to study the mechanisms involved in the relief of dyspnea by the administration of high flow by nasal cannula (HFNC).

Description:

This study will measure the effect of HFNC on an experimental model of dyspnea induced by thoraco-abdominal elastic strapping on healthy subjects at rest.

The study will also compare the effects on dyspnea of the administration of high flow nasal cannula with and without oxygen added.

Recruitment information / eligibility
Status Completed
Enrollment 32
Est. completion date November 2, 2018
Est. primary completion date November 2, 2018
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 18 Years to 70 Years
Eligibility Inclusion Criteria:

- Healthy volunteers

Exclusion Criteria:

- chronic pathology

- active smokers

- anxiety disorder

- allergy to latex

- protected adult

- woman declared herself pregnant

Study Design

Related Conditions & MeSH terms

Intervention

Device:
• Optiflow with an inspired fraction of oxygen of 100%
Respiratory gaz heated and humidified system of delivery with a fraction of oxygen inspired of 100%
• Optiflow with an inspired fraction of oxygen of 21%
Respiratory gaz heated and humidified system of delivery with a fraction of oxygen inspired of 21%

Locations
Country Name City State
France Laboratoire de Physiopathologie Respiratoire du Service de Pneumologie et de Réanimation Paris
France Service de Pneumologie et Réanimation Médicale Paris

Sponsors (1)
Lead Sponsor Collaborator
Association pour le Développement et l'Organisation de la Recherche en Pneumologie et sur le Sommeil

Country where clinical trial is conducted

France, 

Outcome
Type Measure Description Time frame Safety issue
Primary Effects of high flow nasal cannula on strapping induced type of dyspnea Evaluated by visual annylogic scale One hour
Secondary Compare the effect of the high flow by nasal cannula with and without oxygen on an experimental dyspnea, evaluated by the differences of changes in the visual analogic scale Evaluated by visual annylogic scale One hour
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