Healthy Volunteers Clinical Trial
Official title:
The Effect of Losartan on Emotional Processing in Healthy Volunteers
This experimental medicine study explores whether a single dose of losartan (50mg) versus placebo affects the processing of positive and negative stimuli, using fMRI.
Losartan has been shown to accelerate fear extinction in animals and to prevent the
development of anxiety disorders in humans, emphasising its potential to possibly enhance
exposure therapy in humans. This study explores the basic effects of losartan on emotional
processing, to identify neural mechanisms by which the drug might have synergistic effects on
psychological treatment in humans.
In a double-blind between-groups design, 30 healthy volunteers will be randomised to a group
receiving a single dose of losartan (50mg) versus placebo, and this study will measure the
effects of probing renin-angiotensin function on emotional information processing, using
functional magnet resonance imaging (fMRI). Such knowledge will ultimately be essential for
the development of more effective pharmaco-psychological treatment approaches for anxiety
disorders.
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