Sensori-motor and Perceptual Functions of the PPC.

Healthy Volunteers Clinical Trial

— PPCfonctions  

Official title:

Sensori-motor and Perceptual Functions of the Posterior Parietal Cortex (PPC) in Patients With Optic Ataxia (AO) and Healthy Subjects.

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT03286686
• Other study ID #: 69HCL17_0341
• Secondary ID: 2017-A02562-51
• Status: Recruiting
• Phase: N/A
• Start date: February 22, 2018
• Est. completion date: February 22, 2029

Study information

• Verified date: January 2024
• Source: Hospices Civils de Lyon
• Contact: Laure PISELLA, PhD
• Phone: 4 72 91 34 05
• Email: laure.pisella[@]inserm.fr
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

To produce hand's movement directed towards a target, the investigator must combine several sensory information, such as vision or proprioception. The posterior parietal cortex (PPC) is a region of the cortex involved in this multisensory integration. A lesion of the PPC cause a visuo-motor trouble called optic ataxia but these patients also have perceptual troubles.

The aim of the study is to understand the different functions of the PPC and especially how the processes of spatial coding of the sensory information influences perception and motor planning.

In this study, the investigator want to explore the sensory motor and the perceptual performance of patients with optic ataxia compared with healthy subjects, using 6 behavioral tests.

Objectify the consequences of PPC impairment (visual-motor and perceptual consequences) on patients' quality of life and autonomy.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 160
• Est. completion date: February 22, 2029
• Est. primary completion date: February 22, 2029
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 75 Years

Eligibility

Inclusion Criteria:

All patients and healthy subjects:

• male and female, age from 18 to 75 years included

• normal vision or corrected vision

• covered by social security

• signed written informed consent

Patients:

• neurological injury in posterior parietal cortex supported by a cerebral MRI

• present optic ataxia symptoms Healthy subjects

• no known neurological injury

Exclusion Criteria:

• unable to comply with the tasks (neurological, psychiatric, sensory or motor troubles)

Related Conditions & MeSH terms

• Ataxia
• Cerebellar Ataxia
• Healthy Volunteers
• Optic Ataxia

Intervention

Behavioral:
• point targets
In the experiences 1 and 2, the participant needs to point different visual targets (LED) in the dark.
• tactile stimulation
In the experience 3, a tactile stimulation is applied to the middle finger of the 2 hands. The participant needs to indicate into a microphone when he feels the stimulation.
• visual images
Target dots or visual images are presented on a computer screen. The participant is required to point to the targets or to react as soon as possible by pressing a response button when they are detected.

Locations

Country	Name	City	State
France	U1028 INSERM - CNRS UMR 5292 Equipe ImpAct	Bron

Sponsors (1)

Lead Sponsor	Collaborator
Hospices Civils de Lyon

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	response error - number of pointing error		Day 0 after each stimulation
Primary	response error -measure of reaction times		Day 0 after each stimulation
Primary	response error - percentage of right responses		Day 0 after each stimulation