Healthy Volunteers Clinical Trial
Official title:
Magnetic Resonance Cholangiopancreatography (MRCP): A Reliable, Non Invasive Method for Staging Chronic Pancreatitis From Minimal Change Disease to the Advanced Stages in Pediatrics
The goal of this research study is to learn more about the pancreas. The investigators want to use Magnetic Resonance Cholangiopancreatography (MRCP) to learn more about the size of a normal pancreas. MRCP is a special kind of MRI exam that produces detailed images of the pancreas. The investigators also want to figure out how much fluid the pancreas releases in response to secretin. Secretin is a chemical in the body that causes the pancreas to release fluid that helps with digestion. Secretin is used during the MRCP (MR-PFT) to help identify dysfunction of the pancreas. MR elastography (MRE) will be used to measure how hard the pancreas is. MRE is a special kind of MRI that uses vibrations to image tissue.
Introduction/Methods: Pancreatic fibrosis is the end stage of chronic pancreatitis (CP),
which leads to loss of acinar volume and secretory capacity, and ultimately pancreatic
insufficiency (PI). CP and congenital PI affect the pediatric population, and are both
increasingly recognized in children. PI has serious negative implications on a child's growth
and health but, if diagnosed early, PI can be treated, minimizing the detrimental effects of
PI. Currently, direct pancreatic function testing (PFT) via collection of pancreatic fluid is
the "gold standard" for diagnosis of PI but it is an invasive testing that may require
sedation or general anesthesia. Magnetic resonance cholangiopancreatography (MRCP) with
secretin administration (MR-PFT) and MR elastography (MRE) may allow non-invasive, and
potentially early diagnosis of CP and PI. Currently, however, normative data with which to
compare MR-PFT and MRE results in pediatric patients with suspected CP/PI is not available.
Aims: The investigators propose to determine the normal range for secreted pancreatic fluid
volume in response to secretin administration and determine the normal range for pancreatic
parenchymal stiffness in a pediatric population that is not affected by pancreatic disease.
To date, the investigators have validated their MRCP technique and have successfully
performed both MR-PFT and MRE in CP patients; however normative data is essential for
validation of our non-invasive technique.
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