Healthy Volunteers Clinical Trial
Official title:
Gas Exchange and Cardiovascular Kinetics of Regulation - Effects of Short Term Changes in Gravity
The regulation of the cardiovascular respiratory system after changing environmental
conditions or changes in work rates are essential for cognitive as well as physical
functioning. For decades, it is known that high level of headward acceleration (+Gz) impairs
cardiovascular function that may cause loss of consciousness. Some "anti-g" maneuvers, such
as muscle contraction of the lower extremities and buttocks or intermittent exhalation on
exertion (i.e., exhalation against a closed airway) have been proved to increase tolerance
to high +Gz.
Main objective of this experiment is to investigate the effects of anti-g maneuvers on
cardiovascular and respiratory tolerance to the push-pull-effect.
Cardiovascular and respiratory functions will be evaluated with the following parameters:
heart rate, stroke volume, cardiac output, blood pressure, oxygen uptake, carbon dioxide
output, ventilation, breathing frequency, body core temperature.
Electromyography (EMG) will not be a judgment criteria but will be used to check the quality
of 'muscle contraction' anti-g maneuver.
The main hypothesis is that anti-g maneuvers will increase cardiovascular and respiratory
tolerance to the push-pull effect, especially when they are combined.
n/a
Intervention Model: Single Group Assignment, Masking: Open Label
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