Brain Bases of Natural Scenes's Visual Perception of Natural Scenes

Healthy Volunteer Clinical Trial

— SCENES  

Official title:

Brain Bases of Visual Perceptionnatural Scenes of Natural Scenes.

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02840305
• Other study ID #: 38RC11.221
• Status: Completed
• Phase: N/A
• First received: July 18, 2016
• Last updated: January 17, 2017
• Start date: April 2012
• Est. completion date: August 2016

Study information

• Verified date: January 2017
• Source: University Hospital, Grenoble
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Using the available data from psychophysics, cellular electrophysiology and functionnal neuroanatomy of visual pathway, current models of visual recognition suppose that the perception of scenes start with a parallel extraction of differents elementary visual characteristics to different spatial frequencies according to a default processing principle named : 'coarse-to-fine'.

According to this principle, the visual scene's analysis would be decomposed in two steps. Fisrt, the fast analysis of the global information borne by low frequency of the scene will provide an overview of the scene's structure and would enable a first perceptive categorisation which would be then refined, approved or denied by the latest analysis of the most local, detailed and precise information, carried by the very high spatial frequency of the scene.

The research carried out since several years is preparing a biologically plausible model and to find brain bases by different imaging techniques among healthy subjects but also patients with a brain lesion and patients with a peripheral lesion.

The main goal of this Magnetic Resonance Imaging study is to find brain bases of natural scenes's visual perception of the natural scenes.

Three studies in Magnetic Resonance Imaging will be conducted, during which subjects will have to categorize pictures of natural scenes filtered in spatial frequencies. The outcome of this study will allow to refine models of visual recognition, most of them based on analysis of spatial frequencies.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 141
• Est. completion date: August 2016
• Est. primary completion date: March 2016
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 4 Years and older

Eligibility

Inclusion Criteria for young adults :

• Subjet over 18 years and less than 30 years

• Affiliation to a social security

• Free signed consent

• Medical exam done before participation to the study

• Normal or corrected visual acuity

Exclusion Criteria four young adults :

• Counter-argument to MRI

• Pregnant, breast-feeding or parturient women

• Adults non protected or unable to express their consent

• Adults protected

• Important earing or visual disorder

• Neuropsychiatric disorder current or past passée ou présente (exept benign epilepsy)

• Severe affection on a general level (cardiac, respiratory, hematologic, renal, hépatic, cancerous)

• Drug treatment in progress (exept anti-epileptic drug) likely to de modulate brain activity

Inclusion Criteria for old adults :

• Subjet over 50 years

• Affiliation to a social security

• Free signed consent

• Medical exam done before participation to the study

• Normal or corrected visual acuity

Exclusion Criteria four old adults :

• Counter-argument to MRI

• Pregnant, breast-feeding or parturient women

• Adults non protected or unable to express their consent

• Adults protected

• Important earing or visual disorder

• Neuropsychiatric disorder current or past passée ou présente (exept benign epilepsy)

• Severe affection on a general level (cardiac, respiratory, hematologic, renal, hépatic, cancerous)

• Drug treatment in progress (exept anti-epileptic drug) likely to de modulate brain activity

Inclusion Criteria for children :

• Children between 4 and 12 years

• Affiliation to a social security

• Free signed consent

• Medical exam done before participation to the study

• Normal or corrected visual acuity

Exclusion Criteria four children :

• Counter-argument to MRI

• Important earing or visual disorder

• Important development disorder and/or acquisitions identified by parents and/or school teachers

• Neuropsychiatric disorder current or past passée ou présente (exept benign epilepsy)

• Severe affection on a general level (cardiac, respiratory, hematologic, renal, hépatic, cancerous)

• Drug treatment in progress (exept anti-epileptic drug) likely to de modulate brain activity

Related Conditions & MeSH terms

• Healthy Volunteer

Intervention

Other:
• Evaluation of visual function

• Magnetic Resonance Imaging

Locations

Country	Name	City	State
France	UniversityHospitalGrenoble	La Tronche

Sponsors (1)

Lead Sponsor	Collaborator
University Hospital, Grenoble

Country where clinical trial is conducted

France, 

References & Publications (38)

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* Note: There are 38 references in all — Click here to view all references

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Identify brain bases of natural scenes's visual perception of the natural scenes	Evaluation 1 = Visual tasks Experience 1 : Brain bases of spatial frequencies treatment Experience 2 : Brain bases of Computer to Film (CtF) natural scenes analysis MRI exam Experience 3 : Part of parahippocampal gyrus in Computer to Film (CtF) natural scenes analysis MRI exam About 30 minutes; Evaluation 2 = Retinotopy : only adults that have shown activations inside occipital cortex during evaluation 1 MRI exam about 50 minutes	About 80 minutes