Neural Correlates of Intern Speech

Healthy Volunteer Clinical Trial

— INNERSPEECH  

Official title:

Neural Correlates of Intern Speech

Clinical Trial Details — Status: Terminated

Administrative data

• NCT number: NCT02830100
• Other study ID #: 38RC14.304
• Status: Terminated
• Phase: N/A
• Start date: July 23, 2015
• Est. completion date: December 12, 2015

Study information

• Verified date: October 2018
• Source: University Hospital, Grenoble
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The goal is to define what is the nature of intern speech, how it manifests itself, who deal with agency in intern speech and finally what is the role of intern speech in attention tasks.

Description:

Intern speech has a main goal in memory, thinking and self-awareness. So this study might bring information in order to better understand any potential adverse effect on depression or anxiety disorders for example.

Recruitment information / eligibility

• Status: Terminated
• Enrollment: 25
• Est. completion date: December 12, 2015
• Est. primary completion date: December 12, 2015
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 65 Years

Eligibility

Inclusion Criteria:

• Between 18 and 65 years

• Right-handed

• French as mother tongue

• Visual acuity that allow to read stimulis (contact lens authorized)

• Healthy subject

Exclusion Criteria:

• Respiratory or cardio-vascular pathology

• Claustrophobia

Related Conditions & MeSH terms

• Healthy Volunteer

Intervention

Other:
• Healthy volunteers
Magnetic Resonance Imaging during intern speech, listening, talking, thinking.

Device:
• MRI

Locations

Country	Name	City	State
France	UniversityHospitalGrenoble	La Tronche

Sponsors (1)

Lead Sponsor	Collaborator
University Hospital, Grenoble

Country where clinical trial is conducted

France, 

References & Publications (20)

Baciu MV, Rubin C, Décorps MA, Segebarth CM. fMRI assessment of hemispheric language dominance using a simple inner speech paradigm. NMR Biomed. 1999 Aug;12(5):293-8. — View Citation

Basho S, Palmer ED, Rubio MA, Wulfeck B, Müller RA. Effects of generation mode in fMRI adaptations of semantic fluency: paced production and overt speech. Neuropsychologia. 2007 Apr 9;45(8):1697-706. Epub 2007 Jan 16. — View Citation

Bookheimer SY, Zeffiro TA, Blaxton T, Gaillard W, Theodore W. Regional cerebral blood flow during object naming and word reading. Human Brain Mapping. 1995;3:93-106.

Clark A, Karmiloff-Smith A. The cognizer's innards: a psychological and philosophical perspective on the development of thought. Mind & Language. 1993;8:487-519.

Conrad B, Schönle P. Speech and respiration. Arch Psychiatr Nervenkr (1970). 1979 Apr 12;226(4):251-68. — View Citation

Davis RN, Nolen-Hoeksema S. Cognitive inflexibility among ruminators and nonruminators. Cognitive Therapy and Research. 2000;24:699-711.

Frings M, Dimitrova A, Schorn CF, Elles HG, Hein-Kropp C, Gizewski ER, Diener HC, Timmann D. Cerebellar involvement in verb generation: an fMRI study. Neurosci Lett. 2006 Nov 27;409(1):19-23. Epub 2006 Oct 12. — View Citation

Huang J, Carr TH, Cao Y. Comparing cortical activations for silent and overt speech using event-related fMRI. Hum Brain Mapp. 2002 Jan;15(1):39-53. — View Citation

Lupyan G. Extracommunicative functions of language: verbal interference causes selective categorization impairments. Psychon Bull Rev. 2009 Aug;16(4):711-8. doi: 10.3758/PBR.16.4.711. Erratum in: Psychon Bull Rev. 2009 Oct;16(5):986. — View Citation

McGuire PK, Silbersweig DA, Murray RM, David AS, Frackowiak RS, Frith CD. Functional anatomy of inner speech and auditory verbal imagery. Psychol Med. 1996 Jan;26(1):29-38. — View Citation

Morin A. Inner Speech Encyclopedia of Human Behavior. 2012;Elsevier:436-43.

Netsell R, Ashley E, Bakker K. The Inner Speech of Persons who Stutter. Proceedings of the International Motor Speech Conference. Savannah, Georgia2010

Olivers CN, Nieuwenhuis S. The beneficial effects of additional task load, positive affect, and instruction on the attentional blink. J Exp Psychol Hum Percept Perform. 2006 Apr;32(2):364-79. — View Citation

Owen WJ, Borowsky R, Sarty GE. FMRI of two measures of phonological processing in visual word recognition: ecological validity matters. Brain Lang. 2004 Jul-Sep;90(1-3):40-6. — View Citation

Palmer ED, Rosen HJ, Ojemann JG, Buckner RL, Kelley WM, Petersen SE. An event-related fMRI study of overt and covert word stem completion. Neuroimage. 2001 Jul;14(1 Pt 1):182-93. — View Citation

Partovi S, Konrad F, Karimi S, Rengier F, Lyo JK, Zipp L, Nennig E, Stippich C. Effects of covert and overt paradigms in clinical language fMRI. Acad Radiol. 2012 May;19(5):518-25. doi: 10.1016/j.acra.2011.12.017. Epub 2012 Jan 27. — View Citation

Rosen HJ, Ojemann JG, Ollinger JM, Petersen SE. Comparison of brain activation during word retrieval done silently and aloud using fMRI. Brain Cogn. 2000 Mar;42(2):201-17. — View Citation

Shergill SS, Bullmore ET, Brammer MJ, Williams SC, Murray RM, McGuire PK. A functional study of auditory verbal imagery. Psychol Med. 2001 Feb;31(2):241-53. — View Citation

Shuster LI, Lemieux SK. An fMRI investigation of covertly and overtly produced mono- and multisyllabic words. Brain Lang. 2005 Apr;93(1):20-31. — View Citation

Uttl B, Morin A, Faulds TJ, Hall T, Wilson JM. Sampling Inner Speech Using Text Messaging. Proceedings of the Canadian Society for Brain, Behavior, and Cognitive Science. Kingston2012. p. 287.

* Note: There are 20 references in all — Click here to view all references

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Study intern speech	Magnetic Resonance Imaging while talking, thinking, listening	About an hour