Neural Development of Deductive Reasoning

Healthy Volunteers Clinical Trial

— NEUREAS  

Official title:

Neural Development of Deductive Reasoning: an fMRI Study of Relational and Categorical Reasoning in Children

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT02763657
• Other study ID #: 2012.767
• Status: Recruiting
• Phase: N/A
• First received: May 3, 2016
• Last updated: May 3, 2016
• Start date: October 2013
• Est. completion date: December 2016

Study information

• Verified date: May 2016
• Source: Hospices Civils de Lyon
• Contact: Christian SCHEIBER, Pr, MD
• Phone: 4 72 68 49 61
• Email: christian.scheiber[@]chu-lyon.fr
• Is FDA regulated: No
• Health authority: France: Agence Nationale de Sécurité du Médicament et des produits de santé
• Study type: Interventional

Clinical Trial Summary

Children's understanding of linear-order (e.g., Dan is taller than Lisa, Lisa is taller than Jess) and set-inclusion (i.e., All tulips are flowers, All flowers are plants) relationships is critical for the acquisition of deductive reasoning, that is, the ability to reach logically valid conclusions from given premises. Behavioral and neuroimaging studies in adults suggest processing differences between these relations: While arguments that involve linear-orders may be preferentially associated with spatial processing, arguments that involve set-inclusions may be preferentially associated with verbal processing. In this study, we use functional magnetic resonance imaging to investigate how and when these processing differences appear in children from 8 to 14.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 60
• Est. completion date: December 2016
• Est. primary completion date: December 2016
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 8 Years to 14 Years

Eligibility

Inclusion Criteria:

• Right-handed

• Affiliated to the French social security

• Whose parents gave informed consent

Exclusion Criteria:

• Neurological disorders

• Psychiatric disorders

• Birth complications requiring admission into neonatal intensive care unit

• Medication affecting central nervous system processing

• Significant hearing impairment

• Uncorrected visual impairment

• Non-native English speaker

• Contraindications for MRI

Study Design

Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science

Related Conditions & MeSH terms

• Healthy Volunteers

Intervention

Other:
• fMRI scanning
All participants are scanned while evaluating linear-order and set-inclusion reasoning problems

Locations

Country	Name	City	State
France	Hospices Civils de Lyon	Lyon/bron

Sponsors (1)

Lead Sponsor	Collaborator
Hospices Civils de Lyon

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Identification of brain regions engaged in linear-order and set-inclusion reasoning	Brain activity measured using fMRI	30 days	No
Secondary	Degree of overlap between brain regions involved in linear-order and set-inclusion reasoning	Degree of overlap in brain activity measured using fMRI	30 days	No