Healthy Volunteers Clinical Trial
Official title:
Metabolomic Approach to Evaluate the Effect of Orange Juice Intake in Healthy Humans: a Comparative Study Between "Bahia" and "Cara Cara" Orange Varieties.
This study evaluates the effect of intake of two orange juice varieties in healthy adults. The participants will receive "Bahia" orange juice, "Cara-Cara" orange juice or a isocaloric control drink in a cross-over study.
The consumption of fruits and vegetables is linked to a decrease in the incidence of chronic
diseases. Citrus fruits represent the main source of bioactive compounds such as flavonoids,
vitamin C and carotenoids in the brazilian diet.
Unlike the "Bahia", the "Cara Cara" variety which is a spontaneous mutation of "Washington
navel" orange is characterized by a bright red pulp due to high levels of lycopene. This
difference in the chemical composition may lead to a different biological activity and then
a greater protective effect on health.
Since the biological effects generated from a food intake are the result of the interaction
of various nutrients with different metabolic pathways, the investigators will apply the
metabolomic approach to investigate the complex relationships between fruit intake,
bioactive compounds and human metabolism. The investigators will propose to describe the
metabolic pathways affected by orange juice intake and to identify biomarkers that can be
used in nutritional interventions.
;
Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Treatment
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