Clinical Trials Logo
  1. Home
  2. Healthy Volunteers
  3. NCT02616835
  4. Details
NCT02616835 Clinical Trial

Investigating the Physiology of Targeted Theta-burst Neuromodulation

Healthy Volunteers Clinical Trial

Official title:
Investigating the Physiology of Targeted Theta-burst Neuromodulation

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT02616835
Other study ID # L14082014 SoM PAPsych
Secondary ID
Status Completed
Phase N/A
First received November 24, 2015
Last updated November 25, 2015
Start date August 2014
Est. completion date June 2015

Study information
Verified date November 2015
Source Institute of Mental Health Nottingham
Contact n/a
Is FDA regulated No
Health authority United Kingdom: Research Ethics Committee
Study type Interventional

Clinical Trial Summary

This research seeks to study the physiological effects of theta-burst transcranial magnetic stimulation (TMS) in the brains of healthy controls using functional MRI and spectroscopy.

Recruitment information / eligibility
Status Completed
Enrollment 28
Est. completion date June 2015
Est. primary completion date March 2015
Accepts healthy volunteers Accepts Healthy Volunteers
Gender Both
Age group 18 Years to 65 Years
Eligibility Inclusion Criteria:

- No personal history of neurological or psychiatric disorders

Exclusion Criteria:

- Have had a brain injury or neurological disorder

- Have ever suffered an epileptic fit

- Have any non-removable metal implants

- Drink more than 20 units of alcohol per week on a regular basis

- Currently take any illicit drugs on regular basis

- Likely to be pregnant

- Ever suffered from a serious mental illness such as schizophrenia, severe depression or bipolar disorder

- Currently take any psychotropic medication

Study Design

Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Single Blind (Subject), Primary Purpose: Basic Science

Related Conditions & MeSH terms

Intervention

Device:
• theta-burst TMS
This protocol involves short periods of pulse delivery in combination with long periods of silent intervals.
• sham theta-burst TMS
This protocol delivers theta-burst pulses from a sham device (i.e. at same speed and timeframe but without the magnetic output)

Locations
Country Name City State
United Kingdom Sarina Iwabuchi Nottingham Nottinghamshire

Sponsors (1)
Lead Sponsor Collaborator
Institute of Mental Health Nottingham

Country where clinical trial is conducted

United Kingdom, 

Outcome
Type Measure Description Time frame Safety issue
Primary Changes in functional connectivity following TMS administration using functional MRI Changes in brain connectivity will be assessed by comparing functional MRI scans after theta-burst TMS and sham theta-burst TMS One hour No
Secondary Changes in brain metabolites following TMS administration using MR spectroscopy Using MRI scans, changes in metabolites in the brain will be assessed following theta-burst TMS and sham TMS One hour No
See also
  Status Clinical Trial Phase
Completed NCT05001152 - Taste Assessment of Ozanimod Phase 1
Completed NCT05029518 - 3-Way Crossover Study to Compare the PK (Pharmokinetics) and to Evaluate the Effect of Food on the Bioavailability Phase 1
Completed NCT04493255 - A Study to Determine the Metabolism and Elimination of [14C]E7090 in Healthy Male Participants Phase 1
Completed NCT03457649 - IV Dose Study to Assess the Safety, Tolerability, PK, PD and Immunogenicity of ARGX-113 in Healthy Volunteers Phase 1
Completed NCT00995891 - Collection of Blood, Bone Marrow, and Buccal Mucosa Samples From Healthy Volunteers for Center for Human Immunology, Autoimmunity, and Inflammatory Diseases (CHI) Laboratory Research Studies
Completed NCT05050318 - Annual Study for Collection of Serum Samples in Children and Older Adults Receiving the 2021-2022 Formulations of Fluzone Quadrivalent Vaccine and Fluzone High-Dose Quadrivalent Vaccine, Respectively Phase 4
Completed NCT05043766 - Evaluation of Oral PF614 Relative to OxyContin Phase 1
Completed NCT04466748 - A Multiple Ascending Dose Pharmacology Study of Anaprazole in Healthy Chinese Subjects Phase 1
Completed NCT00746733 - Vyvanse and Adderall XR Given Alone and in Combination With Prilosec OTC Phase 1
Recruiting NCT05929651 - Study of Immunogenicity and Safety of MenQuadfi® as a Booster Vaccine in Toddlers 12 to 23 Months, Regardless of the Quadrivalent Meningococcal Conjugate Vaccine Used for Priming in Infancy Phase 4
Completed NCT05954039 - Evaluation of the Efficacy of a Dietary Supplement on Hair Loss and Hair Aspect N/A
Completed NCT05045716 - A Study of Subcutaneous Lecanemab in Healthy Participants Phase 1
Active, not recruiting NCT02747927 - Efficacy, Safety and Immunogenicity of Takeda's Tetravalent Dengue Vaccine (TDV) in Healthy Children Phase 3
Completed NCT05533801 - A Study to Demonstrate the Bioequivalence of Lecanemab Supplied in Vials and a Single-Use Auto-Injector (AI) in Healthy Participants Phase 1
Not yet recruiting NCT03931369 - Adaptation of Thirst to a Single Administration of Tolvaptan (TOLVATHIRST) Phase 2
Completed NCT03279146 - A Single Dose Study Evaluating PK of TXL Oral Formulations in Healthy Subjects Phase 1
Completed NCT06027437 - A Study to Assess the Relative Biological Availability and the Effect of Food on the Drug Levels of Danicamtiv in Healthy Adult Participants Phase 1
Recruiting NCT05619874 - Effects of Two Virtual HIFCT Programs in Adults With Abdominal Obesity N/A
Completed NCT05553418 - Investigational On-body Injector Clinical Study N/A
Completed NCT04092712 - Study Evaluating Pharmacokinetics and Mass Balance of [14C]-CTP-543 in Healthy Adult Male Volunteers Phase 1