Dynamics of Stroke Volume and Cardiac Output During Parabolic Flight, and Its Relationship to Intravascular Volume

Healthy Volunteers Clinical Trial

— DYMCO  

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02518880
• Other study ID #: 09-178
• Status: Completed
• Phase: N/A
• First received: August 6, 2015
• Last updated: August 6, 2015
• Start date: March 2010

Study information

• Verified date: August 2015
• Source: University Hospital, Caen
• Contact: n/a
• Is FDA regulated: No
• Health authority: France: Afssaps - Agence française de sécurité sanitaire des produits de santé (Saint-Denis)
• Study type: Interventional

Clinical Trial Summary

To understand the cardiovascular reactions of the human body to changing conditions of gravity is an important aim of space science. In this context, cardiac output (CO) is a key value to estimate the human cardiovascular system.

The main objective of this experiment is to determine the effects of parabolic flight on intravascular volume, and how these changes modulate the complex haemodynamics induced by the parabolas.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 18
• Est. primary completion date: February 2012
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 18 Years to 55 Years

Eligibility

Inclusion Criteria:

• healthy volunteers (men or women),

• aged from 18 to 55,

• affiliated to a Social Security system,

• who accept to take part in the study,

• who have given their written stated consent,

• who already participated in parabolic flights (even in the same campaign)

• All subjects will pass a medical examination similar to a standard aviation medical examination for private pilot aptitude. There will be no additional test performed for subject selection

Exclusion Criteria:

• person who took part in a previous biomedical research protocol, of which exclusion period is not terminated,

• pregnant women

Study Design

Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science

Related Conditions & MeSH terms

• Healthy Volunteers

Intervention

Other:
• Parabolic flight

• plasma volume measurements

Locations

Country	Name	City	State
France	Umr Ucbn/Inserm U1075 Comete	Caen CEDEX	Basse-Normandie

Sponsors (1)

Lead Sponsor	Collaborator
University Hospital, Caen

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	haemoglobin concentration		baseline	No