Sleep Deprivation : Effects on Driving Performance and Central Fatigue

Healthy Volunteers Clinical Trial

— PrivSom  

Official title:

Effects of Sleep Deprivation on Driving Performance and Central Fatigue

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01606020
• Other study ID #: 1108128
• Secondary ID: 2011-A00895-36
• Status: Completed
• Phase: N/A
• First received: May 3, 2012
• Last updated: August 21, 2012
• Start date: September 2011
• Est. completion date: July 2012

Study information

• Verified date: August 2012
• Source: Centre Hospitalier Universitaire de Saint Etienne
• Contact: n/a
• Is FDA regulated: No
• Health authority: France: Afssaps - Agence française de sécurité sanitaire des produits de santé (Saint-Denis)
• Study type: Interventional

Clinical Trial Summary

The effects of sleep deprivation (SD) on performance, while contradictory at first glance, are in reality rather clear when exercise duration is considered, i.e. intense/supramaximal versus prolonged exercises. This latter type of exercise leads to the most important performance decrements after SD.

Description:

The effects of sleep deprivation (SD) on performance, while contradictory at first glance, are in reality rather clear when exercise duration is considered, i.e. intense/supramaximal vs. prolonged exercises. This latter type of exercise leads to the most important performance decrements after SD. However, the causes of this accentuated fatigability in endurance exercise with sleep deficit are not known. Several hypotheses have been proposed such as lower pH before exercise, lower ventilation due to depreciated response to hypercapnia/hypoxia, or haemodilution. Yet the most plausible explanation is a lower tolerance to prolonged exercise because SD increases the rate of perceived exertion. Another potential effect of SD is an alteration of central command during exercise. The literature is rather scarce on this topic and is only based on a few animal studies. In humans, no effect of SD on maximal strength has been reported so that maximal voluntary activation should in theory not be altered. Transcranial Magnetic Stimulation (TMS), that allows to induce a motor response from its cortical origin (and to measure the resulting contraction), is a promising tool to explore neuromuscular function. TMS has been used only in three studies after SD, none of them involving exercise and none of them measuring mechanical responses (i.e. only EMG responses, such as motor evoked potential, were measured). In addition, the results of these three studies are contradictory. The effects of SD on central fatigue (i.e. increase of the activation deficit during exercise) have never been investigated. The goal of this experiment is thus to test the hypothesis that an increase in central fatigue (at supraspinal level) in SD can participate to performance alteration during a prolonged exercise. For that purpose, measurements of neuromuscular function particularly dedicated to assess central fatigue will be performed before and after SD but also when combining SD and a fatiguing exercise conducted until exhaustion.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 12
• Est. completion date: July 2012
• Est. primary completion date: July 2012
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 18 Years to 50 Years

Eligibility

Inclusion Criteria:

• no smoking and drugs

• regular physical activity

Exclusion Criteria:

• insufficiency cardiac or respiratory

• carrying a cardiac pacemaker

Study Design

Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Basic Science

Related Conditions & MeSH terms

• Healthy Volunteers
• Sleep Deprivation

Intervention

Other:
• sleep deprivation
Overnight, the subjects stay in their homes (reading, watching TV, playing cards). Two experimenters will take turns to never leave them alone and avoid any micro-sleep.
• No intervention
Overnight, the subjects stay in their homes. No intervention during this night

Locations

Country	Name	City	State
France	CHU de Saint-Etienne	Saint-etienne

Sponsors (1)

Lead Sponsor	Collaborator
Centre Hospitalier Universitaire de Saint Etienne

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	change value of the level of maximal voluntary activation of quadriceps muscle supraspinal	change value of the level of maximal voluntary activation of quadriceps muscle supraspinal between before and after endurance exercise after a night of sleep deprivation	at Day 7 and Day 28	No
Secondary	variation of the activation level of excitability and supraspinal / cortical	variation of the activation level of excitability and supraspinal / cortical inhibition after a night of sleep deprivation	At Day 7 and Day 28	No
Secondary	level variation in test performance from test of Simon	level variation in test performance from test of Simon before, during and after endurance exercise following a night of sleep deprivation	At Day 7 and Day 28	No