Healthy Volunteers Clinical Trial
Official title:
Glyceryl-Trinitrate-Induced Headache in Patients With Familial Hemiplegic Migraine Type 1 and 2
The aim of the present study is to explore functional consequences of migraine gene mutations on their responses to GTN infusion.
Glyceryl trinitrate (GTN) induces migraine attacks indistinguishable from spontaneous
attacks in approximately 80% of migraine sufferers. After systemic administration GTN is
transformed to nitric oxide (NO). Treatment of spontaneous migraine attacks with an
inhibitor of NO is effective in 60% of patients. These data show that NO is involved in both
initiation and maintenance of migraine attack.
The consequence of migraine gene mutations on relevant migraine pathways has never been
tested. The aim of the present study is to explore functional consequences of migraine gene
mutations on their responses to GTN infusion. The project will improve our understanding of
the neurobiology of migraine and stimulate development of new treatment targets.
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Allocation: Non-Randomized, Endpoint Classification: Pharmacodynamics Study, Intervention Model: Single Group Assignment, Masking: Single Blind, Primary Purpose: Educational/Counseling/Training
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