View clinical trials related to Healthy Volunteers.
Filter by:This is a Phase 1, open-label, nonrandomized, single-dose human, absorption, metabolism, and excretion study of [14C]-Fosgonimeton
A critical point in learning and memory research is whether memories, once consolidated, remain unchanged or whether they continue to undergo plastic changes and remodeling. While previous research has focused on experimental destabilization during early stages of the memory life cycle, i.e., during encoding or early consolidation, experimental data that provides information about the effect of destabilization interventions on well-consolidated memories is still missing. This is particularly true for the procedural memory domain, such as learning a sensorimotor skill. This project is designed to characterize the effect of a single behavioral interference intervention on a previously consolidated sensorimotor skill in a large sample of healthy volunteers recruited through an online crowdsourcing platform. In a longitudinal design, participants will perform an implicit sequence learning task over five consecutive sessions, followed by an interference intervention in session six and a follow-up evaluation of the stability of the learned skill in session seven. The experimental design includes two levels of sequential information (spatial and temporal), which allows the testing of the specificity of the interference intervention. Behavioral performance throughout the experimental sessions is acquired via the manual input on the participants' computer keyboards and used to extract the learning rate and the interference effect (primary outcome).
The trial medicine (LEO 152020) is being developed to treat people with eczema. The aims of this trial are to find out about: - How the trial medicine affects participant's heart rhythm. - How much of the trial medicine is absorbed into the bloodstream, and how quickly the body gets rid of it. - The safety of the trial medicine and any side effects that might be related to it. The trial will last up to 45 days, and there will be up to 6 visits. Four treatment periods are planned for this trial. In each treatment period, participant will receive a single dose of the trial medicine at dose A, trial medicine at dose B, dummy tablet, or an approved medication named moxifloxacin (used for the treatment of bacterial infections). The order of these 4 treatment periods is chosen at random. Participant will receive all 4 treatments; it is only the order of the treatments that is random. There will be 6 trial visits and they will include 1 screening visit, 4 treatment period visits and 1 final, follow-up visit at the clinic. The 4 treatment period visits will last for 3 days, from Day -1 (check-in to the clinic) to Day 2 (check-out of the clinic). There will be a period of at least 3 days between the 4 dosing occasions.
Phase 1, open-label study designed to evaluate safety, tolerability, pharmacokinetic, and pharmacodynamic of multiple doses of BION-1301 in Japanese healthy subjects.
The purpose of this FIH study is to evaluate the safety, tolerability and pharmacokinetics of ONO-2020 in healthy adult participants. This FIH study consists of five parts (Parts A-E) to study single or multiple doses of ONO-2020 in healthy participants, including elderly and Japanese participants, as well as the food effect on the PK of ONO-2020. These data will support the clinical development program and help inform dose selection in future studies.
This is a phase I, single-center, randomized, open-label, single-dose, three-period (fasting, high-fat meal, low-fat meal) crossover clinical study to investigate the food effect on PK of the recommended phase II dose (RP2D) of 300 mg Glumetinib, based on the previous clinical studies of Glumetinib monotherapy.
CB03-154 is an investigational drug developed by Shanghai Zhimeng Biopharma Inc. for the treatment of Epilepsy.
Crossfit® is a high-intensity physical training plan based on a program that includes exercises such as running, weight lifting and gymnastic movements. It focuses on the development of 10 physical qualities: strength, balance, cardiovascular and respiratory endurance, coordination, power, flexibility, agility, speed, precision and muscular endurance.Unfortunately, research on its effects is still at the beginning. The time of each session is one hour, which is divided into a warm-up of 10-30 minutes, strength training or skills, endurance work and finally a recovery phase, mobility and stretching. These types of exercises are incorporated into group training sessions called Workout of The Day (WOD). Muscular strength is the action produced by a muscle or muscle group against resistance. It is one of the fundamental physical qualities for activities of daily living. Digital isometric dynamometry is a tool to evaluate maximum voluntary isometric contraction (MVIC). Hamstring muscles are responsible for hip extension and knee flexion. Moreover, they are the main protectors against anterior knee subluxation due to their action in conjunction with the anterior cruciate ligament (ACL).The quadriceps is one of the largest and most powerful muscles of the human body. The ratio between hamstrings and quadriceps muscles has a strong correlation with lower limb injuries. This ratio, known as "H:Q" has proved to be the most reliable indicator to quantify a neuromuscular decompensation that causes an injury and, in addition, it is used as a prognostic indicator.
This is a post market, single-center, randomized, controlled, clinical study to assessTo evaluate the performance of self-administered Sentinox intranasal spray in preventing ARI caused by at least one respiratory virus
CB03-154 is an investigational drug developed by Shanghai Zhimeng Biopharma Inc. for the treatment of Epilepsy.