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Clinical Trial Details — Status: Recruiting

Administrative data

NCT number NCT05805033
Other study ID # 2022/189
Secondary ID B7072022000023
Status Recruiting
Phase N/A
First received
Last updated
Start date September 22, 2023
Est. completion date September 1, 2024

Study information

Verified date November 2023
Source Centre Hospitalier Universitaire de Liege
Contact Clémentine Canuel, MsD
Phone +33679097264
Email clementine.canuel@hotmail.fr
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

The purpose of this study is to compare the mucointegration of 2 types of surface roughness of zirconia abutments with titanium. The surface roughness will be machined and ultra-polished.


Description:

After being informed about the study and potential risks, all participants give written informed consent and eligibility for study entry. The day of the surgery, patients will be randomized in machined zirconia or ultra-polished zirconia. After 8 weeks of healing, biopsy are separated in two groups according to the removal: - if the abutment come together with the surrounding soft tissues, it goes for a non decalcified histology for histometric measurements to determine the dimensions of biological width (sulcus depth, epithelial and connective adhesion) - if the abutment come separate of the surrounding tissue, the soft tissue goes for immunohistochemistry to analyse pro-inflammatory cells and vascularisation and the abutment for SEM analysis to calculate the percentage of adhesion of the cells on the abutment


Recruitment information / eligibility

Status Recruiting
Enrollment 40
Est. completion date September 1, 2024
Est. primary completion date May 1, 2024
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria: - Participants have to voluntarily sign the informed consent form before any study related action - Patients aged 18 or over - Patients with one or more missing teeth in the maxillary or mandible area, seeking implant therapy - Men/women - Patients in good systemic health (ASA I/ II) and no contraindication for oral surgical interventions - Patients requiring a replacement of missing teeth; the tooth at the implant site(s) must have been extracted or lost at least 12 weeks before the date of implantation - At least 3 mm of fibrous mucosa in the bucco-lingual dimension - Full mouth plaque score (FMPI) lower than or equal to 25% - At least a diameter of 4 mm for the implant (regular diameter) Exclusion Criteria: - Autoimmune disease requiring medical treatment - Medical conditions requiring prolonged use of steroids - Use of Bisphosphonates intravenously or more than 3 years of oral use - Infection (local or systemic) - patients with gingivitis or active local infection will undergo a medical treatment prior to the entrance to the study, and each individual will be evaluated for suitability; in case of a systemic infection, the evaluation will be based on medical anamneses, and if necessary, a patient will be referred to relevant medical tests - Current pregnancy or breastfeeding women - Alcoholism or chronical drug abuse - Immunocompromised patients - Uncontrolled diabetes - Smokers - Prisoners - Implant's diameter under 4 mm (narrow implant) - Conditions or circumstances, in the opinion of the investigator, which would prevent completion of the study or interference with analysis of study results, such as history of non-compliance, or unreliability

Study Design


Related Conditions & MeSH terms


Intervention

Other:
Mucointegration
Placement of abutment on a dental implant to study mucointegration

Locations

Country Name City State
Belgium Clémentine Canuel Liège

Sponsors (1)

Lead Sponsor Collaborator
Centre Hospitalier Universitaire de Liege

Country where clinical trial is conducted

Belgium, 

Outcome

Type Measure Description Time frame Safety issue
Primary Histomorphometry Height measure of biological width (sulcus depth, epithelial and connective adhesion) 8 weeks of healing
Primary Immunohistology Analysis of the pro-inflammatory cells and vascularisation of the soft tissue + analysis of the percentage of cells adhesion on the abutment 8 weeks of healing
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