Non-invasive BCI for Cognitive Enhancement

Healthy Subjects Clinical Trial

Official title:

Non-invasive Brain Computer Interface for Cognitive Enhancement

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05311878
• Other study ID #: 2020030073_p2
• Status: Completed
• Phase: N/A
• Start date: January 1, 2021
• Est. completion date: November 1, 2023

Study information

• Verified date: November 2023
• Source: University of Texas at Austin
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

People's perceptual skills can significantly affect their abilities to make optimal decisions, judgments, and actions in real-world dynamic environments. Perceptual learning refers to training and experiences to induce improvements in the ability to make sense of what people see, hear, feel, taste or smell based on ambiguous sensory information. In this study, investigators hypothesise that there exist neural signatures that robustly encode the conscious visual perception of rotations of a cursor and the magnitudes of these rotations in a novel, rotation-based perceptual learning task. Investigators also hypothesise that online, instantaneous EEG-based feedback on subjects' visual perceptions of rotations with an EEG-based Brain Computer Interface (BCI) can foster perceptual learning much more effectively than behaviour perceptual training, especially in very small rotation magnitudes that represent extremely difficult perceptual tasks.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 32
• Est. completion date: November 1, 2023
• Est. primary completion date: November 1, 2023
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 80 Years

Eligibility

Inclusion Criteria:

Able-bodied volunteers:

• good general health

• normal or corrected vision

• no history of neurological/psychiatric disease

• ability to read and understand English

• ability to understand information and ability to give a free and informed consent

Subjects with neuropsychiatric diseases

• Subjects with neuropsychiatric diseases such as bipolar disorder and schizophrenia.

• normal or corrected vision

• ability to read and understand English

• ability to understand information and ability to give a free and informed consent

Exclusion Criteria:

• short attentional spans or cognitive deficits that prevent to remain concentrated during the experimental sessions

• concomitant serious illnesses (e.g., metabolic disorders, cardiac arrest)

• factors hindering proper EEG acquisition (e.g., scalp wound, uncontrolled muscle activity)

Related Conditions & MeSH terms

• Healthy Subjects
• Neuropsychiatric Disorders

Intervention

Device:
• EEG-based perceptual training
Electroencephalography (EEG) signals will be recorded from subjects as they perform rotation-based perceptual tasks. The neural correlates of conscious perception of rotations will be processed and decoded in real-time using machine learning algorithms to provide feedback. Subjects are instructed to assume a mental state/find a strategy to maximise the accuracy of feedback. In total, each subject will complete 5 sessions of perceptual training with this intervention.
• Behavior based perceptual training
Subjects complete the rotation-based perceptual tasks, and ground truth visual feedback is provided indicating whether subjects have spotted the rotations correctly. Subjects are instructed to spot as many rotation as possible to maximise the accuracy of feedback. In total, each subject will complete 5 sessions of perceptual training with this intervention.

Locations

Country	Name	City	State
United States	Engineering Education and Research Center	Austin	Texas

Sponsors (1)

Lead Sponsor	Collaborator
University of Texas at Austin

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Change in correct answer rate of different rotation magnitudes across 5 intervention sessions	The correct answer rate per rotation magnitude reflects the improvements in perceptual skills across the two conditions. It measures the percentage of each rotation magnitude spotted correctly. The score is 0-100, and the higher the value, the better the outcome.	Difference is measured every 24 hours, before versus after each intervention session
Secondary	Change in neural correlates of conscious perception across 5 intervention sessions	This outcome measures whether neural correlates of conscious perception (e.g. amplitude, peak-to-peak, band power and connectivity measures of neural correlates) change across sessions as a result of intervention.	Difference is measured every 24 hours, before versus after each intervention session