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Clinical Study to Investigate Effect of Macitentan on Riociguat Pharmacokinetics

Healthy Subjects Clinical Trial

Official title:
A Single-center, Open-label, One-sequence, Two-treatment Study to Investigate the Effect of Macitentan at Steady State on the Pharmacokinetics of Riociguat in Healthy Male Subjects

Clinical Trial Summary

Both macitentan and riociguat are indicated in the treatment of pulmonary arterial hypertension (PAH) and may be administered concomitantly. The primary objective of this study is to evaluate the effect of macitentan administered for 11 days on the pharmacokinetics (PK) (i.e., amount and time of presence in the blood of riociguat) of a single dose of riociguat in healthy male subjects.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03389321
Study type Interventional
Source Actelion
Contact
Status Completed
Phase Phase 1
Start date January 9, 2018
Completion date February 6, 2018
View Details
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