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Pharmacokinetic Interaction Between Diltiazem and ACT-541468 in Healthy Subjects

Healthy Subjects Clinical Trial

Official title:
A Single-center, Open-label, Randomized, Two-way Crossover Study to Investigate the Effect of Multiple-dose Diltiazem on the Pharmacokinetics of a Single Dose of 25 mg ACT-541468 in Healthy Male Subjects

Clinical Trial Summary

The main objective of this study is to investigate whether repeated administration of a cardiac medication (diltiazem) can affect the pharmacokinetics (i.e., amount and time of presence in the blood) of ACT-541468

Clinical Trial Description

Because ACT-541468 appears to be mainly metabolized by CYP3A4, it is deemed of interest to investigate the potential influence of diltiazem, a well-known CYP3A4 inhibitor on the pharmacokinetic profile of ACT-541468.

Safety of the concomitant administration of the two drugs will also be assessed ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02526888
Study type Interventional
Source Idorsia Pharmaceuticals Ltd.
Contact
Status Completed
Phase Phase 1
Start date September 1, 2015
Completion date November 1, 2015
View Details
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