Healthy Subjects Clinical Trial
— ANALOGOfficial title:
Organisation du Cortex préfrontal ventrolatéral Pour l'Analogie: Approche Bimodale Chez le Sujet Sain et Chez le Patient Ayant un Syndrome Frontal.
Verified date | March 2017 |
Source | Institut National de la Santé Et de la Recherche Médicale, France |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Frontal patients are impaired in categorisation and analogical reasoning tasks, and different functional imaging studies from our group have shown the involvement of the prefrontal cortex in categorisation and analogy tasks. The aim of this project is to test our hypotheses about the role of the prefrontal cortex in explicit and implicit categorisation and analogy tasks.
Status | Completed |
Enrollment | 130 |
Est. completion date | February 2021 |
Est. primary completion date | February 2021 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 20 Years to 85 Years |
Eligibility | Inclusion Criteria: Healthy subjects: - subject affiliated to national health insurance - informed consent signed - normal neurological examination - subject aged at least 20 Patients: - FTD or PSP diagnostic criteria filled - patient affiliated to national health insurance - informed consent signed Exclusion Criteria: - Severe psychiatric symptomatology and psychotropic drug use - unability to understand or perform the cognitive tasks. |
Country | Name | City | State |
---|---|---|---|
France | ICM (Institut du cerveau et de la Moelle épinière) | Paris |
Lead Sponsor | Collaborator |
---|---|
Institut National de la Santé Et de la Recherche Médicale, France | Fondation pour la Recherche Médicale |
France,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Performance in the implicat task | Reaction time and accuracy will be registered for this categorization task. This task will be used in patients with FTD and in healthy controls (n=60). Participants will come only once during one day ot the research centre. |
day of inclusion (one day) | |
Primary | Performance in the Similitude task | Reaction time and accuracy will be recorded while healthy subjects perform this categorization task, after a session of rTMS or during on line TMS (n=40). Participants will come 3 to 5 times at the research centre in a maximum period of 4 months. |
from inclusion to 4 months after inclusion | |
Secondary | recording of EEG | EEG will be recorded in patients with FTD and in healthy controls for an analysis of event related potentials. Participants will come only once during one day a the research centre. |
day of inclusion (one day) | |
Secondary | Analysis of MRI | T1 MRI will be recorded for VBM analysis in patients with FTD and healthy controls. Participants will come only once during one day at the research centre |
day of inclusion (one day) |
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