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Cortical Representation of Hyperalgesia Induced by Nerve Growth Factor — LOGIN_NGF  

Healthy Subjects Clinical Trial

Official title:
Cortical Representation of NGF-induced Hyperalgesia

Clinical Trial Summary

Intraepidermal injection of nerve growth factor results in a non-inflammatory hyperalgesia for thermal and mechanical stimuli. This hyperalgesia is similar to the pathological ailments of patients with neuropathic pain. The mechanisms of the cognitive modulation of pain and hyperalgesia are not yet understood in this group of patients. The investigators plan to use NGF injection as a model of non-inflammatory neuropathic pain in healthy subjects to investigate the underlying neuronal mechanisms of this hyperalgesia using functional magnetic resonance imaging and resting state network analysis.

Clinical Trial Description

n/a

Study Design

Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02159170
Study type Interventional
Source Central Institute of Mental Health, Mannheim
Contact
Status Completed
Phase N/A
Start date March 2014
Completion date December 2014
View Details
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