Healthy Subjects Clinical Trial
Official title:
Effects of Exercise on Fructose Metabolism
A high fructose diet increases fasting and post-prandial triglyceride (TG) concentrations in
sedentary healthy human subjects.These effects may be secondary to fructose-induced hepatic
de novo lipogenesis. Recent evidence indicate that exercise can prevent fructose induced
dyslipidemia.This study will evaluate
1. how exercise effects the metabolic fate of oral fructose 1a) when exercise is performed
before fructose ingestion 1b) when exercise is performed after fructose ingestion
Metabolic effects of exercise will be assessed in healthy male subjects by measuring
fructose oxidation (13CO2 production), fructose conversion into glucose (13C glucose
concentrations in blood) and hepatic fructose conversion into lipid (13C palmitate-very
low density lipoprotein (VLDL) concentrations in blood) after ingestion of 13C-labelled
fructose meals
2. how fructose and protein modulate muscle glycogen and intramyocellular lipid repletion
after exercise Healthy male subjects will be fed various fructose, glucose, lipid and
whey protein meals after a glycogen/intramyocellular lipid depleting exercise. The
effects of meals' composition will be assessed after 24 hours by measuring
intramyocellular lipids and glycogen using proton-magnetic resonance spectroscopy
(MRS).
n/a
Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Basic Science
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