Healthy Subjects Clinical Trial
Official title:
Clinical Assessment of Negative Symptoms Neurocognitive and Electrophysiological Characteristics in Chronic Cannabis Users
The aim of the current study is set out to find a human model for negative symptoms based on
clinical observation that chronic cannabis users express negative symptoms and characterize
by the same neurocognitive and electrophysiology characteristics like patient suffer from
schizophrenia. Towards that end the first part of the study is set out to explore weather
chronic cannabis user's express negative symptoms similar to patient suffer from
schizophrenia. The second part of the study will explore the neurocognitive and
electrophysiology characteristics of those cannabis users that express negative symptoms.
This data will be compared to parallel data of schizophrenia patients with predominantly
negative symptom.
Several lines of biological and genetic evidence support the cannabinoid hypothesis for
schizophrenia. Particularly, it is most significant clinically that the possible involvement
of the cannabinoid system in the neural basis for the negative symptoms. This hypothesis
based on clinical findings that chronic cannabis use causes a combination of symptoms
including apathy, avolition, lack of interest, passivity, and cognitive impairments, the
so-called "amotivational syndrome," which resembles the core negative symptoms of
schizophrenia in behavioral level as well as the brain level. Both are associated with the
functions or integrity of the frontal lobe due to its role in creating self-directed
behaviors, deficits in which may underlie alogia, anhedonia, and flat affect. Despite the
aforementioned similarities, to date, there is no documentation for such a relationship.
Recognition that chronic cannabis users share the same or similar constellation of symptoms
and similar neurocognitive and electrophysiology characteristics could provide a key to
develop a human model for negative symptoms and an essential tool to comprehensive
understanding of the etiology of negative symptoms and development of an innovative therapy.
The investigators Hypothesize That Chronic Cannabis Users Would Express the Same
Constellation of Behaviors as Negative Symptoms of Schizophrenia; as well as similar
neurocognitive and electrophysiology characteristics
n/a
Allocation: Non-Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Diagnostic
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