Effects of Increased Muscle Mass on Resting Metabolic Rate

Healthy Subjects Clinical Trial

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01325038
• Other study ID #: Beach08
• Status: Completed
• Phase: N/A
• First received: March 28, 2011
• Last updated: March 28, 2011
• Start date: January 2008
• Est. completion date: August 2009

Study information

• Verified date: March 2011
• Source: University Hospital, Linkoeping
• Contact: n/a
• Is FDA regulated: No
• Health authority: Sweden: Regional Ethical Review Board
• Study type: Interventional

Clinical Trial Summary

Healthy males are randomized to isometric exercise for three months with either extra protein or extra calories in the form of a fast food meal/day in order to study if increase in muscle mass increases resting metabolic rate and if this is affected by presumed increased caloric intake as compared with only proteins.

Body-composition was measured with Dual-Energy X-ray Absorbimetry (DEXA) and RMR was measured by registration of CO2 production and O2 consumption.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 24
• Est. completion date: August 2009
• Est. primary completion date: June 2008
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 18 Years to 45 Years

Eligibility

Inclusion Criteria:

• healthy males

Exclusion Criteria:

• significant disease

• inability to exercise

Study Design

Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Basic Science

Related Conditions & MeSH terms

• Healthy Subjects

Intervention

Procedure:
• Isometric exercise
Isometric exercise several times/week for three months

Locations

Country	Name	City	State
Sweden	University Hospital of Linkoping	Linkoping

Sponsors (1)

Lead Sponsor	Collaborator
University Hospital, Linkoeping

Country where clinical trial is conducted

Sweden, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	change in resting metabolic rate	measurement of resting metabolic rate at baseline and at the end of the three month trial period	3 months	No
Secondary	change in muscle mass	measurement of muscle mass with DEXA at baseline and at the end of the three month trial period	3 months	No