Effects of Betaine Supplementation on Strength and Muscle Creatine Content

Healthy Subjects Clinical Trial

Official title:

Effects of Betaine Supplementation Combined or Not With Creatine Supplementation on Muscle Creatine Content and Strength

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01213719
• Other study ID #: betaine supplementation
• Status: Completed
• Phase: N/A
• First received: October 1, 2010
• Last updated: January 12, 2012
• Start date: October 2010
• Est. completion date: July 2011

Study information

• Verified date: January 2012
• Source: University of Sao Paulo
• Contact: n/a
• Is FDA regulated: No
• Health authority: Brazil: National Committee of Ethics in Research
• Study type: Interventional

Clinical Trial Summary

It has been suggested that betaine supplementation may improve muscle strength by increasing muscle creatine content. However, there is no data supporting this assumption. The investigators speculate that betaine supplementation could enhance intramuscular creatine content, which would result in strength improvements.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 40
• Est. completion date: July 2011
• Est. primary completion date: July 2011
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 18 Years to 30 Years

Eligibility

Inclusion Criteria:

• physically inactive

• non-obese

Exclusion Criteria:

• skeletal muscle disturbance

• cardiovascular disturbance

• use of dietary supplements

Study Design

Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator)

Related Conditions & MeSH terms

• Healthy Subjects

Intervention

Dietary Supplement:
• creatine
20g/d throughout 10 days
• betaine
2g/d throughout 10 days
• dextrose
dextrose (placebo), 20 g/d throughout 10 days
• creatine plus betaine
creatine (20g/d) plus betaine (2g/d) throughout 10 days

Locations

Country	Name	City	State
Brazil	University of Sao Paulo	Sao Paulo

Sponsors (1)

Lead Sponsor	Collaborator
University of Sao Paulo

Country where clinical trial is conducted

Brazil, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	strength		after 10 days	No
Secondary	intramuscular creatine content		after 10 days	No